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Article
Open AccessPrevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase
Neuraminidase (NA) of human influenza H3N2 virus has evolved rapidly and been accumulating mutations for more than half-century. However, biophysical constraints that govern the evolutionary trajectories of NA...
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Article
Open AccessSequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain
Since the COVID-19 pandemic onset, the antibody response to SARS-CoV-2 has been extensively characterized. Antibodies to the receptor binding domain (RBD) on the spike protein are frequently encoded by IGHV3-5...
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Article
Open AccessEvolutionary history of the extant amphioxus lineage with shallow-branching diversification
Amphioxus or lancelets have been regarded as a key animal in understanding the origin of vertebrates. However, the evolutionary history within this lineage remains unexplored. As the amphioxus lineage has like...
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Article
Open AccessDecelerated genome evolution in modern vertebrates revealed by analysis of multiple lancelet genomes
Vertebrates diverged from other chordates ~500 Myr ago and experienced successful innovations and adaptations, but the genomic basis underlying vertebrate origins are not fully understood. Here we suggest, thr...