17 Result(s)

Article

Author Correction: Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis

Zhaoxian Cai, **aotian Wu, Zijun Song, Shumin Sun, Yunxing Su… in Cell Discovery (2024)

Article

Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis

Given the rapidly aging population, aging-related diseases are becoming an excessive burden on the global healthcare system. Metformin has been shown to be beneficial to many age-related disorders, as well as ...

Zhaoxian Cai, **aotian Wu, Zijun Song, Shumin Sun, Yunxing Su… in Cell Discovery (2023)

Article

Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) continue to wreak havoc across the globe. Higher transmissibility and immunologic resistance of VOCs bring unprecedented ...

Hang Ma, Yingying Guo, Haoneng Tang, Chien-Te K. Tseng, Lei Wang… in Cell Discovery (2022)

Article

Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection

A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is urgently needed to tackle the COVID-19 global pandemic. Here, we describe the development of chimpanzee adenovir...

Jiaojiao Liu, Kun Xu, Man **ng, Yue Zhuo, **gao Guo, Meng Du, Qi Wang… in Cell Discovery (2021)

Article

Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals

SARS-CoV-2 outbreak has been declared by World Health Organization as a worldwide pandemic. However, there are many unknowns about the antigen-specific T-cell-mediated immune responses to SARS-CoV-2 infection....

Lingjie Luo, Wenhua Liang, Jianfeng Pang, Gang Xu, Yingying Chen… in Cell Discovery (2021)

Article

Generation of human blastocyst-like structures from pluripotent stem cells

Human blastocysts are comprised of the first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm, all of which are essential for early development and organ formation. However, du...

Yong Fan, Zheying Min, Samhan Alsolami, Zhenglai Ma, E. Zhang, Wei Chen… in Cell Discovery (2021)

Article

Cryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations

Substitution of lysine 36 with methionine in histone H3.3 (H3.3K36M) is an oncogenic mutation that inhibits SETD2-mediated histone H3K36 tri-methylation in tumors. To investigate how the oncohistone mutation a...

Yingying Liu, Yanjun Zhang, Han Xue, Mi Cao, Guohui Bai, Zongkai Mu… in Cell Discovery (2021)

Article

Author Correction: Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans

A Correction to this paper has been published: https://doi.org/10.1038/s41421-021-00251-8

Tianbin Liu, Jie Li, Leqian Yu, Hai-** Sun, **g Li, Guoyi Dong… in Cell Discovery (2021)

Article

Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans

Interspecies blastocyst complementation enables organ-specific enrichment of xenogeneic pluripotent stem cell (PSC) derivatives, which raises an intriguing possibility to generate functional human tissues/orga...

Tianbin Liu, Jie Li, Leqian Yu, Hai-** Sun, **g Li, Guoyi Dong… in Cell Discovery (2021)

Article

Sensitivity and specificity of SARS-CoV-2 S1 subunit in COVID-19 serology assays

Ying Tian, Chaoyang Lian, Yingying Chen, Dong Wei, **nxin Zhang, Yun Ling… in Cell Discovery (2020)

Article

USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment

Previous studies have implicated an essential role for UHRF1-mediated histone H3 ubiquitination in recruiting DNMT1 to replication sites for DNA maintenance methylation during S phase of the cell cycle. Howeve...

Jialun Li, Rui** Wang, Jianyu **, Mengmeng Han, Zhaosu Chen… in Cell Discovery (2020)

Article

Efficient engulfment of necroptotic and pyroptotic cells by nonprofessional and professional phagocytes

Jiongcong Lu, Wenke Shi, Bo Liang, Chang’an Chen, Rui Wu, Huaipeng Lin… in Cell Discovery (2019)

Article

Hemi-methylated CpG sites connect Dnmt1-knockdown-induced and Tet1-induced DNA demethylation during somatic cell reprogramming

The relationship between active DNA demethylation induced by overexpressing Tet1 and passive DNA demethylation induced by suppressing Dnmt1 remains unclear. Here, we found that DNMT1 preferentially methylated, bu...

Songwei He, Fuhui Wang, Yixin Zhang, **long Chen, Lining Liang, Yuan Li… in Cell Discovery (2019)

Article

Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice

SLC39A14 (also known as ZIP14), a member of the SLC39A transmembrane metal transporter family, has been reported to mediate the cellular uptake of iron and zinc. Recently, however, mutations in the SLC39A14 gene ...

Yongjuan **n, Hong Gao, Jia Wang, Yuzhen Qiang, Mustapha Umar Imam… in Cell Discovery (2017)

Article

Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation

Out of the breast cancer subtypes, triple-negative breast cancer (TNBC) has the poorest prognosis without effective targeted therapies. Metformin, a first-line drug for type 2 diabetes mellitus, was demonstrat...

Peiguo Shi, Wen**g Liu, Tala, Haixia Wang, Fubing Li, Hailin Zhang… in Cell Discovery (2017)

Article

Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity

Wnt/β-catenin signaling regulates multiple biological processes and aberration of this pathway is frequently observed in human cancers. Previously, we uncovered NC043 as a small-molecule inhibitor of Wnt/β-cat...

**aoli He, Wenjuan Zhang, Chen Yan, Fen Nie, Chen Li, **aofen Liu… in Cell Discovery (2017)

Article

TRAIP regulates replication fork recovery and progression via PCNA

PCNA is a central scaffold that coordinately assembles replication and repair machineries at DNA replication forks for faithful genome duplication. Here, we describe TRAIP (RNF206) as a novel PCNA-interacting ...

Wanjuan Feng, Yingying Guo, Jun Huang, Yiqun Deng, Jianye Zang… in Cell Discovery (2016)