39 Result(s)

Article

Immunometabolism in cancer: basic mechanisms and new targeting strategy

Maturing immunometabolic research empowers immune regulation novel approaches. Progressive metabolic adaptation of tumor cells permits a thriving tumor microenvironment (TME) in which immune cells always lose ...

Ranran Su, Yingying Shao, Manru Huang, Donghui Liu, Haiyang Yu… in Cell Death Discovery (2024)

Article

NCAPD3 exerts tumor-promoting effects in prostatic cancer via dual impact on miR-30a-5p by STAT3-MALAT1 and MYC

Non-SMC condensin II complex subunit D3 (NCAPD3) is a subunit of the non-structural maintenance of chromosomes condensin II complex, which involves chromosome condensation and segregation during mitosis. NCAPD...

Yi Zhang, Yingying Shao, Jia Ren, Yuanyuan Fang, Bolin Yang… in Cell Death Discovery (2024)

Article

Inhibition of the ILK-AKT pathway by upregulation of PARVB contributes to the cochlear cell death in Fascin2 gene knockout mice

The Fscn2 (Fascin2) gene encodes an actin cross-linking protein that is involved in the formation of hair cell stereocilia and retina structure. Mutations in Fscn2 gene have been linked to hearing impairment and ...

Rongrong Liu, Wen**g Shang, Yingying Liu, Yi **e, Jun Luan… in Cell Death Discovery (2024)

Article

Author Correction: Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis

Zhaoxian Cai, **aotian Wu, Zijun Song, Shumin Sun, Yunxing Su… in Cell Discovery (2024)

Article

Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis

Given the rapidly aging population, aging-related diseases are becoming an excessive burden on the global healthcare system. Metformin has been shown to be beneficial to many age-related disorders, as well as ...

Zhaoxian Cai, **aotian Wu, Zijun Song, Shumin Sun, Yunxing Su… in Cell Discovery (2023)

Article

Haspin balances the ratio of asymmetric cell division through Wnt5a and regulates cell fate decisions in mouse embryonic stem cells

Many different types of stem cells utilize asymmetric cell division (ACD) to produce two daughter cells with distinct fates. Haspin-catalyzed phosphorylation of histone H3 at Thr3 (H3T3ph) plays important role...

Yingying Gao, Bin Ma, Yifan Li, **angyu Wu, Shifeng Zhao… in Cell Death Discovery (2023)

Article

Emerging roles of ferroptosis-related miRNAs in tumor metastasis

Ferroptosis, a novel mode of cell death dependent on iron and reactive oxygen species, has been extensively explored during malignant tumors metastasis. Ferroptosis can interact with multiple components of the...

Zhongyi Jiang, **g Zhou, Junqi Deng, Luohong Li, Ruifeng Wang… in Cell Death Discovery (2023)

Article

Aminoprocalcitonin protects against hippocampal neuronal death via preserving oxidative phosphorylation in refractory status epilepticus

Refractory status epilepticus (RSE) is a neurological emergency where sustaining seizure causes severe neuronal death. Currently, there is no available neuroprotectant effective in RSE. Aminoprocalcitonin (NPC...

Changgeng Song, **g**g Zhao, Jianmin Hao, Dan Mi, Jiajia Zhang… in Cell Death Discovery (2023)

Article

Correction to: NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress

Yi Wang, Yuxin Zan, Yingying Huang, **aoyun Peng, Shinan Ma, Ji Ren… in Cell Death Discovery (2023)

Article

JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a chronic disorder characterized by hyperproliferation of pulmonary arterial smooth muscle cells (PASMCs). JMJD1C, a member of the Jumonji domain containing C (JMJC) hi...

Chen Zhang, Yue Sun, Yingying Guo, **g**g Xu, Haiyan Zhao in Cell Death Discovery (2023)

Article

Correction to: LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury

Peixing Wan, Wenru Su, Yingying Zhang, Zhidong Li… in Cell Death & Differentiation (2023)

Article

NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress

Doxorubicin (DOX) is a commonly used antitumor drug, but its application has been limited because of its strong cardiac damage. This study aims to explore the role of NSUN2 in DOX-induced heart injury. C57BL/6...

Yi Wang, Yuxin Zan, Yingying Huang, **aoyun Peng, Shinan Ma, Ji Ren… in Cell Death Discovery (2023)

Article

Human-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest

Exploring the functions of human-specific genes (HSGs) is challenging due to the lack of a tractable genetic model system. Testosterone is essential for maintaining human spermatogenesis and fertility, but the...

Chao Li, Yuming Feng, Zhenxin Fu, Junjie Deng, Yue Gu, Hanben Wang… in Cell Death Discovery (2022)

Article

RBM47 inhibits hepatocellular carcinoma progression by targeting UPF1 as a DNA/RNA regulator

The mechanisms by which the tumor behaviors of hepatocellular carcinoma (HCC) support growth and metastasis remain largely unknown, and it has become increasingly apparent that molecular dysregulation is of co...

Tao Guo, Ke You, ** Chen, Yuqi Sun, Ying Wu, ** Wu… in Cell Death Discovery (2022)

Article

Gankyrin modulated non-small cell lung cancer progression via glycolysis metabolism in a YAP1-dependent manner

Non-small cell lung cancer (NSCLC) is highly malignant and heterogeneous form of lung cancer and involves various oncogene alterations. Glycolysis, an important step in tumor metabolism, is closely related to ...

Tong Yu, Yanyan Liu, Junwen Xue, **ang Sun, Di Zhu, Lu Ma… in Cell Death Discovery (2022)

Article

Silencing of lncRNA MALAT1 facilitates erastin-induced ferroptosis in endometriosis through miR-145-5p/MUC1 signaling

Endometriosis is a chronic disorder characterized by the implantation of endometrial glands and stroma outside the uterus. However, the pathogenesis of endometriosis is still unclear. To date, there is no full...

Zongwen Liang, Qiong Wu, Honglin Wang, Jiahuan Tan, Han Wang… in Cell Death Discovery (2022)

Article

ICA69 aggravates ferroptosis causing septic cardiac dysfunction via STING trafficking

Previous studies have demonstrated that cardiomyocyte apoptosis, ferroptosis, and inflammation participate in the progress of sepsis-induced cardiomyopathy (SIC). Although Islet cell autoantigen 69 (ICA69) is ...

Chang Kong, Xuqing Ni, Yixiu Wang, Anqi Zhang, Yingying Zhang… in Cell Death Discovery (2022)

Article

Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) continue to wreak havoc across the globe. Higher transmissibility and immunologic resistance of VOCs bring unprecedented ...

Hang Ma, Yingying Guo, Haoneng Tang, Chien-Te K. Tseng, Lei Wang… in Cell Discovery (2022)

Article

Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection

A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is urgently needed to tackle the COVID-19 global pandemic. Here, we describe the development of chimpanzee adenovir...

Jiaojiao Liu, Kun Xu, Man **ng, Yue Zhuo, **gao Guo, Meng Du, Qi Wang… in Cell Discovery (2021)

Article

Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals

SARS-CoV-2 outbreak has been declared by World Health Organization as a worldwide pandemic. However, there are many unknowns about the antigen-specific T-cell-mediated immune responses to SARS-CoV-2 infection....

Lingjie Luo, Wenhua Liang, Jianfeng Pang, Gang Xu, Yingying Chen… in Cell Discovery (2021)