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  1. Article

    Author Correction: RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

    Zhentao Yang, Yan Wang, Yingying Zhang, **adi He, Chuan-Qi Zhong… in Nature Cell Biology (2024)

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    Article

    O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins

    N6-methyladenosine (m6A) is the most abundant internal mRNA nucleotide modification in mammals, regulating critical aspects of cell physiology and differentiation. The YTHDF proteins are the primary readers of m6

    Yulin Chen, Ruixi Wan, Zhongyu Zou, Lihui Lao, Guojian Shao… in Nature Cell Biology (2023)

  3. Article

    Open Access

    Z-DNA is remodelled by ZBTB43 in prospermatogonia to safeguard the germline genome and epigenome

    Mutagenic purine–pyrimidine repeats can adopt the left-handed Z-DNA conformation. DNA breaks at potential Z-DNA sites can lead to somatic mutations in cancer or to germline mutations that are transmitted to th...

    Yingying Meng, Guliang Wang, Hongjuan He, Kin H. Lau, Allison Hurt… in Nature Cell Biology (2022)

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    Article

    Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses

    As one of the most induced genes in activated macrophages, immune-responsive gene 1 (IRG1) encodes a mitochondrial metabolic enzyme catalysing the production of itaconic acid (ITA). Although ITA has an anti-infla...

    Lei-Lei Chen, Carmen Morcelle, Zhou-Li Cheng, … in Nature Cell Biology (2022)

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    Article

    RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

    Receptor-interacting protein kinase 3 (RIP3)-regulated production of reactive oxygen species (ROS) positively feeds back on tumour necrosis factor (TNF)-induced necroptosis, a type of programmed necrosis. Glut...

    Zhentao Yang, Yan Wang, Yingying Zhang, **adi He, Chuan-Qi Zhong… in Nature Cell Biology (2018)

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    Article

    Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch

    Obesity occurs when excess energy accumulates in white adipose tissue (WAT), whereas brown adipose tissue (BAT), specialized for energy expenditure through thermogenesis, potently counteracts obesity. Factors ...

    Jiqiu Wang, Ruixin Liu, Feng Wang, Jie Hong, **aoying Li… in Nature Cell Biology (2013)