134 Result(s)
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Article
Strand interruptions confer strand preference during intracellular correction of a plasmid-borne mismatch in Saccharomyces cerevisiae
Site-directed mutagenesis was used to construct yeast centromere plasmids in which a strand nick or gap could be placed 5′ or 3′, on either strand, to a reporter gene (SUP4-o) carrying defined base mismatches. T...
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Three Novel Mutations of the PHEX Gene in Three Chinese Families with X-linked Dominant Hypophosphatemic Rickets
X-linked dominant hypophosphatemia (XLH, OMIM307800), the most prevalent form of inherited rickets in humans, is a dominant disorder of phosphate homeostasis characterized by growth retardation, rachitic and o...
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Article
A Recurrent Mutation c.617G>A in the ACVR1 Gene Causes Fibrodysplasia Ossificans Progressiva in Two Chinese Patients
Fibrodysplasia ossificans progressiva (FOP; OMIM 135100) is a rare heritable disorder of connective tissue characterized by congenital malformations of the great toes and recurrent episodes of painful soft tis...
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One Novel Mitochondrial Citrate Synthase from Oryza sativa L. can Enhance Aluminum Tolerance in Transgenic Tobacco
Rice exhibits the greatest aluminum (Al) tolerance compared with other cereals such as wheat, barley, maize, etc. A full-length gene, OsCS1, encoding citrate synthase, which is highly induced by aluminum toxicity...
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Article
Influences of chronic contamination of oil field exploitation on soil nematode communities at the Yellow River Delta of China
Oil production related activities have led to many environmental problems. Around 80% of the total output of crude oil is generated from terrestrial oilfields in the world. However, the impact of oil exploitat...
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Multi-dimensional correlative imaging of subcellular events: combining the strengths of light and electron microscopy
To genuinely understand how complex biological structures function, we must integrate knowledge of their dynamic behavior and of their molecular machinery. The combined use of light or laser microscopy and ele...
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Article
UBE2W interacts with FANCL and regulates the monoubiquitination of fanconi anemia protein FANCD2
Fanconi anemia (FA) is a rare cancer-predisposing genetic disease mostly caused by improper regulation of the monoubiquitination of Fanconi anemia complementation group D2 (FANCD2). Genetic studies have indica...
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Article
Effects of Acupuncture on Glycometabolic Enzymes in Multi-infarct Dementia Rats
Acupuncture has exhibited therapeutic effects on vascular dementia in our previous research. The mechanism of its anti-dementia effects involves energy metabolism. For brain cells, glucose metabolism is almost...
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Article
SPontaneous Oscillatory Contraction (SPOC): auto-oscillations observed in striated muscle at partial activation
Striated muscle is well known to exist in either of two states—contraction or relaxation—under the regulation of Ca2+ concentration. Described here is a less well-known third, intermediate state induced under con...
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Article
Driving efficiency in a high-throughput metabolic stability assay through a generic high-resolution accurate mass method and automated data mining
Improving analytical throughput is the focus of many quantitative workflows being developed for early drug discovery. For drug candidate screening, it is common practice to use ultra-high performance liquid ch...
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Article
SNObase, a database for S-nitrosation modification
S-Nitros(yl)ation is a ubiquitous redox-based post-translational modification of protein cysteine thiols by nitric oxide or its derivatives, which transduces the bioactivity of nitric oxide (NO) by regulation o.....
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Article
Bone morphogenetic protein 9 overexpression reduces osteosarcoma cell migration and invasion
Transforming growth factor-β (TGF-β) is known to promote tumor migration and invasion. Bone morphogenetic proteins (BMPs) are members of the TGF-β family expressed in a variety of human carcinoma cell lines. T...
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Open AccessA partial pathway- and network-based transformation reveals the synergistic mechanism of JA and UA against cerebral ischemia-reperfusion injury
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Article
A novel oxaliplatin derivative, Ht-2, triggers mitochondrion-dependent apoptosis in human colon cancer cells
Ht-2 is a novel oxaliplatin derivative previously identified in a compound screen performed by our laboratory. In the present study, we evaluated the antitumor effects of Ht-2 and investigated its underlying ...
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Article
Quantitative Assessment of the Association Between CYP17 rs743572 Polymorphism and Prostate Cancer Risk
Published data on the association between CYP17 rs743572 polymorphism and risk of PC showed inconclusive results. The aim of this study was to further estimate the pooled effect size of rs743572 polymorphism and ...
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Article
Effects of Lettuce Glycoside B in Ameliorating Pulmonary Fibrosis Induced by Irradiation Exposure and its Anti-Oxidative Stress Mechanism
The present research assessed the effects of lettuce glycoside B (LGB), a compound separated and purified from Pterocypsela laciniata, on irradiation-induced pulmonary fibrosis and explored the me...
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Article
Open AccesshCLP46 increases Smad3 protein stability via inhibiting its ubiquitin-proteasomal degradation
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Article
Open AccessErratum to: hCLP46 increases Smad3 protein stability via inhibiting its ubiquitin-proteasomal degradation
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Article
Bcl-2 silencing attenuates hypoxia-induced apoptosis resistance in pulmonary microvascular endothelial cells
Pulmonary arterial hypertension (PAH) is a life-threatening disorder that ultimately causes heart failure. While the underlying causes of this condition are not well understood, previous studies suggest that t...
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Article
Generation of Human Embryonic Stem Cell Line Expressing zsGreen in Cholinergic Neurons Using CRISPR/Cas9 System
Lineage specific human embryonic stem cell (hESC) reporter cell line is a versatile tool for biological studies on real time monitoring of differentiation, physiological and biochemical features of special cel...
