189 Result(s)

Article

Vitamin C inactivates c-Jun N-terminal kinase to stabilize heart and neural crest derivatives expressed 1 (Hand1) in regulating placentation and maintenance of pregnancy

Vitamin C (VC) serves as a pivotal nutrient for anti-oxidation process, metabolic responses, and stem cell differentiation. However, its precise contribution to placenta development and gestation remains obscu...

Haibin Zhu, Huan Luo, **aowei Wu, Hangyang Bao… in Cellular and Molecular Life Sciences (2024)

Article

A novel deep-benthic sea cucumber species of Benthodytes (Holothuroidea, Elasipodida, Psychropotidae) and its comprehensive mitochondrial genome sequencing and evolutionary analysis

The holothurians, commonly known as sea cucumbers, are marine organisms that possess significant dietary, nutritional, and medicinal value. However, the National Center for Biotechnology Information (NCBI) cur...

Yingying He, Hancheng Zhao, Yongxin Wang, Changfeng Qu, **angxing Gao… in BMC Genomics (2024)

Article

Correction: NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation

Yuanbo Hu, Chenbin Chen, **nya Tong, Sian Chen, **an**g Hu… in Cell Death & Disease (2024)

Article

Integrative analysis of genomic and epigenomic regulation reveals miRNA mediated tumor heterogeneity and immune evasion in lower grade glioma

The expression dysregulation of microRNAs (miRNA) has been widely reported during cancer development, however, the underling mechanism remains largely unanswered. In the present work, we performed a systematic...

Zhen Yang, **aocen Liu, Hao Xu, Andrew E. Teschendorff… in Communications Biology (2024)

Article

ADT-OH exhibits anti-metastatic activity on triple-negative breast cancer by combinatorial targeting of autophagy and mitochondrial fission

High basal autophagy and enhanced mitochondrial fission in triple-negative breast cancer (TNBC) cells support cell migration and promote plasticity of cancer cell metabolism. Here, we suggest a novel combinati...

Shihui Yu, Zhiting Cao, Fangfang Cai, Yingying Yao, **aoyao Chang… in Cell Death & Disease (2024)

Article

Coronin 2B deficiency induces nucleolar stress and neuronal apoptosis

In eukaryotes, the nucleolus is the critical non-membranous organelle within nuclei that is responsible for ribosomal DNA (rDNA) transcription and ribosome biogenesis. The transcription of rDNA, a rate-limitin...

Hongjiao Wu, Yujie Yang, Wanying Yi, Yue Qiu, Shuangshuang Ma… in Cell Death & Disease (2024)

Article

IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer

There is a paucity of comprehensive knowledge pertaining to the underlying mechanisms leading to gefitinib resistance in individuals diagnosed NSCLC harboring EGFR-sensitive mutations who inevitably develop re...

Hengxiao Lu, Jiangshan Ai, Yingying Zheng, Wolong Zhou… in Cell Death & Disease (2024)

Article

Single-nucleus sequencing reveals enriched expression of genetic risk factors in extratelencephalic neurons sensitive to degeneration in ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive loss of motor function linked to degenerating extratelencephalic neurons/Betz cells (ETNs). The reasons why th...

Francesco Limone, Daniel A. Mordes, Alexander Couto, Brian J. Joseph… in Nature Aging (2024)

Article

Author Correction: RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

Zhentao Yang, Yan Wang, Yingying Zhang, **adi He, Chuan-Qi Zhong… in Nature Cell Biology (2024)

Article

Immunometabolism in cancer: basic mechanisms and new targeting strategy

Maturing immunometabolic research empowers immune regulation novel approaches. Progressive metabolic adaptation of tumor cells permits a thriving tumor microenvironment (TME) in which immune cells always lose ...

Ranran Su, Yingying Shao, Manru Huang, Donghui Liu, Haiyang Yu… in Cell Death Discovery (2024)

Article

The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb

Rheb is a small G protein that functions as the direct activator of the mechanistic target of rapamycin complex 1 (mTORC1) to coordinate signaling cascades in response to nutrients and growth factors. Despite ...

Ran Feng, Feng Liu, Ruofei Li, Zhifen Zhou, Zhuoheng Lin, Song Lin… in Cell Research (2024)

Article

NSUN2 relies on ALYREF to regulate Nrf2-mediated oxidative stress and alleviate Dox-induced liver injury

Doxorubicin (Dox) is associated with various liver injuries, limiting its clinical utility. This study investigates whether NSUN2 participates in Dox-induced liver injury and the associated molecular mechanism.

Yingying Huang, **ao Li, Lin Wei, Shinan Ma, Liming Ma, Yuxin Zan… in Biology Direct (2024)

Article

Comprehensive genomic analysis of the SARS-CoV-2 Omicron variant BA.2.76 in **ing City, China, 2022

This study aims to analyze the molecular characteristics of the novel coronavirus (SARS-CoV-2) Omicron variant BA.2.76 in **ing City, China.

Qiang Yin, Wei Liu, Yajuan Jiang, Qiang Feng, **aoyu Wang, Huixin Dou… in BMC Genomics (2024)

Article

SPADE: spatial deconvolution for domain specific cell-type estimation

Understanding gene expression in different cell types within their spatial context is a key goal in genomics research. SPADE (SPAtial DEconvolution), our proposed method, addresses this by integrating spatial ...

Yingying Lu, Qin M. Chen, Lingling An in Communications Biology (2024)

Article

NCAPD3 exerts tumor-promoting effects in prostatic cancer via dual impact on miR-30a-5p by STAT3-MALAT1 and MYC

Non-SMC condensin II complex subunit D3 (NCAPD3) is a subunit of the non-structural maintenance of chromosomes condensin II complex, which involves chromosome condensation and segregation during mitosis. NCAPD...

Yi Zhang, Yingying Shao, Jia Ren, Yuanyuan Fang, Bolin Yang… in Cell Death Discovery (2024)

Article

Bacterial capsules: Occurrence, mechanism, and function

In environments characterized by extended multi-stress conditions, pathogens develop a variety of immune escape mechanisms to enhance their ability to infect the host. The capsules, polymers that bacteria secr...

Shuji Gao, Wenjie **, Yingying Quan, Yue Li, Yamin Shen… in npj Biofilms and Microbiomes (2024)

Article

Inhibition of the ILK-AKT pathway by upregulation of PARVB contributes to the cochlear cell death in Fascin2 gene knockout mice

The Fscn2 (Fascin2) gene encodes an actin cross-linking protein that is involved in the formation of hair cell stereocilia and retina structure. Mutations in Fscn2 gene have been linked to hearing impairment and ...

Rongrong Liu, Wen**g Shang, Yingying Liu, Yi **e, Jun Luan… in Cell Death Discovery (2024)

Article

Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL

Necroptosis is a kind of programmed cell death that causes the release of damage-associated molecular patterns and inflammatory disease including skin inflammation. Activation of receptor-interacting serine/th...

**gyi Li, **ngfeng Liu, Yuanyuan Liu, Fangmin Huang, Jiankun Liang… in Cell Death & Disease (2024)

Article

Retraction Note: Periostin secreted by cancer-associated fibroblasts promotes cancer stemness in head and neck cancer by activating protein tyrosine kinase 7

Binbin Yu, Kailiu Wu, Xu Wang, Jianjun Zhang, Lizhen Wang… in Cell Death & Disease (2024)

Article

Author Correction: Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis

Zhaoxian Cai, **aotian Wu, Zijun Song, Shumin Sun, Yunxing Su… in Cell Discovery (2024)