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  1. No Access

    Article

    AdipoRon Ameliorates Synaptic Dysfunction and Inhibits tau Hyperphosphorylation through the AdipoR/AMPK/mTOR Pathway in T2DM Mice

    There is growing evidence showing that adiponectin (APN) can improve Alzheimer’s disease(AD)-like pathological changes by improving insulin resistance. However, the role of AdipoRon (an Adiponectin receptor ag...

    Wenyan Zhao, Wei Zhang, Yingying Hu, Yuliang Zhou, **ying Zhao… in Neurochemical Research (2024)

  2. No Access

    Article

    Isorhynchophylline Relieves Ferroptosis-Induced Nerve Damage after Intracerebral Hemorrhage Via miR-122-5p/TP53/SLC7A11 Pathway

    Isorhynchophylline (IRN), a component of traditional Chinese herb Uncaria rhynchophylla, possesses strong antioxidant activity. Ferroptosis induced by iron overload causes cell oxidative stress after intracerebra...

    Haikang Zhao, **aoqiang Li, Lei Yang, Liang Zhang, **aobing Jiang… in Neurochemical Research (2021)

  3. No Access

    Article

    Hypermethylation of Mitochondrial Cytochrome b and Cytochrome c Oxidase II Genes with Decreased Mitochondrial DNA Copy Numbers in the APP/PS1 Transgenic Mouse Model of Alzheimer’s Disease

    Alzheimer’s disease (AD) is the most common cause of dementia. Increasing evidence shows that mitochondrial DNA (mtDNA) methylation plays an essential role in many diseases related to mitochondrial dysfunction...

    Yingying Xu, Ling Cheng, **g Sun, Fan Li, **angtian Liu, Yan Wei… in Neurochemical Research (2021)

  4. No Access

    Article

    Transplantation of IFN-γ Primed hUCMSCs Significantly Improved Outcomes of Experimental Autoimmune Encephalomyelitis in a Mouse Model

    The aim of this study was to investigate potential therapeutic effects of IFN-γ primed human umbilical cord mesenchymal stem cell (IFN-γ-hUCMSCs) transplantation on experimental autoimmune encephalomyelitis (E...

    **aoyan Zhou, **aoli Liu, Li Liu, Chao Han, Zhaohong **e… in Neurochemical Research (2020)

  5. No Access

    Article

    Antinociceptive Effect of Spirocyclopiperazinium Salt Compound DXL-A-24 and the Underlying Mechanism

    The antinociceptive effects of spirocyclopiperazinium salt compound DXL-A-24 on neuropathic pain and chemical-stimulated pain were investigated in this study. After the administration of DXL-A-24, the paw with...

    Ding Wang, Hua Yang, Yingying Liang, **n Wang, **aolei Du… in Neurochemical Research (2019)

  6. No Access

    Article

    Generation of Human Embryonic Stem Cell Line Expressing zsGreen in Cholinergic Neurons Using CRISPR/Cas9 System

    Lineage specific human embryonic stem cell (hESC) reporter cell line is a versatile tool for biological studies on real time monitoring of differentiation, physiological and biochemical features of special cel...

    **g Zhou, Chencheng Wang, Kunshan Zhang, Yingying Wang, … in Neurochemical Research (2016)

  7. No Access

    Article

    Effects of Acupuncture on Glycometabolic Enzymes in Multi-infarct Dementia Rats

    Acupuncture has exhibited therapeutic effects on vascular dementia in our previous research. The mechanism of its anti-dementia effects involves energy metabolism. For brain cells, glucose metabolism is almost...

    Lan Zhao, Peng Shen, Yingying Han, Xuezhu Zhang, Kun Nie… in Neurochemical Research (2011)