19 Result(s)
within
Ying Du
Biomedicine, general
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Article
Open AccessComparing the effects of pulsed and radiofrequency catheter ablation on quality of life, anxiety, and depression of patients with paroxysmal supraventricular tachycardia: a single-center, randomized, single-blind, standard-controlled trial
Radiofrequency catheter ablation (RFCA) may lead to decreased quality of life (QOL) and increased anxiety and depression in patients with paroxysmal supraventricular tachycardia (PSVT), possibly due to the lac...
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Article
Dhx33 promotes B-cell growth and proliferation by controlling activation-induced rRNA upregulation
Upon recognition of foreign antigens, naïve B cells undergo rapid activation, growth, and proliferation. How B-cell growth and proliferation are coupled with activation remains poorly understood. Combining CRI...
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Article
Open AccessLncRNA MEG3 promotes cisplatin sensitivity of cervical cancer cells by regulating the miR-21/PTEN axis
Cervical cancer (CC) is a common gynecological malignancy worldwide. Some patients perform serious resistance after chemotherapy, and long-stranded non-coding RNA MEG3 is reported to be involved in the regulat...
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Article
Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity
Neutrophils are derived from bone marrow hematopoietic stem cells (HSCs) and are the largest population among circulating white blood cells in humans, acting as the first line of defense against invading patho...
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Article
Open AccessPreimmunization correlates of protection shared across malaria vaccine trials in adults
Identifying preimmunization biological characteristics that promote an effective vaccine response offers opportunities for illuminating the critical immunological mechanisms that confer vaccine-induced protect...
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Article
Open AccessTransitioning from acute to chronic pain: a simulation study of trajectories of low back pain
Identifying how pain transitions from acute to chronic is critical in designing effective prevention and management techniques for patients’ well-being, physically, psychosocially, and financially. There is an...
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Article
IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3
Intestinal stem cells (ISCs) are maintained by stemness signaling for precise modulation of self-renewal and differentiation under homeostasis. However, the way in which intestinal immune cells regulate the se...
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Article
The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity
Cyclic diadenylate monophosphate (c-di-AMP) is secreted by bacteria as a secondary messenger. How immune cells detect c-di-AMP and initiate anti-bacterial immunity remains unknown. We found that the endoplasmi...
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Article
Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression
Long noncoding RNAs contribute to the cell-type-specific regulation of gene expression. Fan and colleagues identify a unique conserved lncRNA, lncKdm2b, that is transcribed divergently from the Kdm2b gene and is ...
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Article
Open AccessLeptin decreases the expression of low-density lipoprotein receptor via PCSK9 pathway: linking dyslipidemia with obesity
Previous studies have suggested that people with obesity showed elevated serum levels of leptin as well as lipid dysfunction and proprotein convertase subtilisin/kexin type 9 (PCSK9) played an important role i...
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Article
Erratum: Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity
Nat. Immunol.; 10.1038/ni.3356; corrected online 29 February 2016 In the version of this article initially published online, the title of the legend to Figure 1 (“Mice deficient in CCP5 or CCP5 are susceptible...
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Article
Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity
cGAS is an important sensor of cytosolic DNA, but the mechanisms that regulate it remain largely unknown. Fan and colleagues demonstrate that cGAS and its DNA-binding activities are negatively regulated by glu...
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Article
Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection
Fan and colleagues show that Sox2, already known to function as a transcription factor that controls lineage specification during embryogenesis, also has a role as a cytosolic and sequence-specific sensor of b...
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Article
Oscillations and synchrony in a cortical neural network
In this paper, the oscillations and synchronization status of two different network connectivity patterns based on Izhikevich model are studied. One of the connectivity patterns is a randomly connected neurona...
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Article
Firing pattern and synchronization property analysis in a network model of the olfactory bulb
In the olfactory system, both the temporal spike structure and spatial distribution of neuronal activity are important for processing odor information. In this paper, a biophysically-detailed, spiking neuronal...
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Article
Synchronization study in ring-like and grid-like neuronal networks
In this paper, we study the synchronization status of both two gap-junction coupled neurons and neuronal network with two different network connectivity patterns. One of the network connectivity patterns is a ...
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Article
Using interspike intervals to quantify noise effects on spike trains in temperature encoding neurons
This paper examines how noise interacts with the non-linear dynamical mechanisms of neuronal stimulus. We study the spike trains generated by a minimal Hodgkin-Huxley type model of a cold receptor neuron. The ...
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Article
Interaction between ACC synthase 1 and 14-3-3 proteins in rice: a new insight
In this study, the interaction between rice 14-3-3 protein and 1-aminocyclopropane carboxylic acid synthase (ACS) was observed in yeast cells using yeast two-hybrid assays. Given the fact that 14-3-3 proteins ...
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Article
A genome scan localizes five non–MHC loci controlling collagen–induced arthritis in rats
Identification of specific genetic loci that contribute to susceptibility to rheumatoid arthritis (RA) in humans has been hampered by several factors, including: i) multiple interacting genetic loci contributi...
