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Article
Open AccessThe E2F3/miR-125a/DKK3 regulatory axis promotes the development and progression of gastric cancer
Gastric cancer (GC) is one of the most common malignant tumours with high mortality and metastasis rates. E2F3, miR-125a and DKK3 have been reported to be involved in various cancer types, but their detailed r...
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Article
Open AccessmicroRNA-211 regulates cell proliferation, apoptosis and migration/invasion in human osteosarcoma via targeting EZRIN
In recent years, microRNA-211 (miR211) has been considered as a tumor suppressor in multiple malignancies. However, the function of miR211 in human osteosarcoma has not been explored intensively so far. In thi...
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Article
Surface Modification of Polymeric Nanoparticles with M2pep Peptide for Drug Delivery to Tumor-Associated Macrophages
Tumor-associated macrophages (TAMs) with immune-suppressive M2-like phenotype constitute a significant part of tumor and support its growth, thus making an attractive therapeutic target for cancer therapy. To ...
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Article
Open AccessOverexpression of DHX32 contributes to the growth and metastasis of colorectal cancer
Our previous work demonstrates that DHX32 is upregulated in colorectal cancer (CRC) compared to its adjacent normal tissues. However, how overexpressed DHX32 contributes to CRC remains largely unknown. In this...
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Article
ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance
ATM- and RAD3-related (ATR)/Chk1 and ataxia–telangiectasia mutated (ATM)/Chk2 signalling pathways play critical roles in the DNA damage response. Here we report that the E3 ubiquitin ligase Smurf1 determines c...
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Article
Overexpression of Dickkopf 3 in hepatoblastomas and hepatocellular carcinomas
Dickkopf 3 (Dkk3) is a protein expressed at a very early stage of hepatogenesis. In this study, we examined whether Dkk3 was related to a premature or dedifferentiated nature in hepatoblastomas (HBLs) and hepa...
