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Article
Open AccessMulti-charmed and singled charmed hadrons from coalescence: yields and ratios in different collision systems at LHC
We study the production of charmed and multi-charmed hadrons in ultra-relativistic Heavy Ion Collisions coupling the transport approach for charm dynamics in the medium to an hybrid hadronization model of coal...
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Article
Open AccessCACA guidelines for holistic integrative management of esophageal carcinoma
Esophageal carcinoma (EC) is a common malignant tumor of the upper digestive tract worldwide. An analysis of the latest data from cancer centers in China showed that the incidence of EC and the number of death...
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Article
Open AccessGANT-61 induces cell cycle resting and autophagy by down-regulating RNAP III signal pathway and tRNA-Gly-CCC synthesis to combate chondrosarcoma
Chondrosarcoma is ineffective for conventional radiotherapy and chemotherapy with a poor prognosis. Hedgehog (Hh) signal pathway plays a crucial role in tumor growth and progression, which is constitutive acti...
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Article
Open AccessAbnormal signal pathways and tumor heterogeneity in osteosarcoma
Osteosarcoma (OS) is the most frequent and aggressive primary malignant sarcoma among adolescents and chemotherapy has not substantially progressed for decades. New insights into OS development and therapeutic...
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Article
Open AccessIdentification of a novel WAS mutation and the non-splicing effect of a second-site mutation in a Chinese pedigree with Wiskott–Aldrich syndrome
Wiskott–Aldrich syndrome (WAS) is a rare X-linked immunodeficiency disorder caused by abnormal expression of the WAS protein (WASp) due to mutations in the WAS gene, and is generally characterized by microthrombo...
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Article
Open AccessEvent-shape engineering analysis of D meson in ultrarelativistic heavy-ion collisions
We describe the propagation of charm quarks in the quark-gluon plasma (QGP) by means of an event-by-event transport approach. In our calculations the non-perturbative interaction between heavy quarks and light...
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Article
Open AccessThree-arm phase II trial comparing camrelizumab plus chemotherapy versus camrelizumab plus chemoradiation versus chemoradiation as preoperative treatment for locally advanced esophageal squamous cell carcinoma (NICE-2 Study)
Preoperative chemoradiotherapy (CRT) with CROSS regimen has been the recommended treatment for locally advanced esophageal squamous cell carcinoma (ESCC). The addition of programmed cell death protein 1 (PD-1)...
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Article
Open AccessClinical validation of a 90-gene expression test for tumor tissue of origin diagnosis: a large-scale multicenter study of 1417 patients
Once malignancy tumors were diagnosed, the determination of tissue origin and tumor type is critical for clinical management. Although the significant advance in imaging techniques and histopathological approa...
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Article
Open AccessThe signature of charge dependent directed flow observables by electromagnetic fields in heavy ion collisions
We discuss the generation of the directed flow \(v_1(p_T,y_z)\) ...
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Article
Open AccessThe possibility of endoscopic treatment of cN0 submucosal esophageal cancer: results from a surgical cohort
We analyzed the pathological characteristics and recurrence pattern of cN0 submucosal esophageal cancer after esophagectomy and conducted risk stratification to determine the feasibility of performing endoscop...
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Article
Open AccessGene expression profiling for the diagnosis of multiple primary malignant tumors
The incidence of multiple primary malignant tumors (MPMTs) is rising due to the development of screening technologies, significant treatment advances and increased aging of the population. For patients with a ...
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Article
Correction to: MGUS Predicts Worse Prognosis in Patients with CoronaryArtery Disease
The captions to Figures 1–4 in this article as originally published were mismatched with the figures themselves.
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Article
Open AccessMGUS Predicts Worse Prognosis in Patients with Coronary Artery Disease
We performed a retrospective cohort study to analyze all 87 CAD patients with MGUS and 178 CAD patients without MGUS admitted in Zhongshan Hospital Fudan University from 2015 to 2017. Patients were followed up...
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Article
Open AccessStudy of collective anisotropies \(v_2\) and \(v_3\) and their fluctuations in pA collisions at LHC within a relativistic transport approach
We have developed a relativistic transport approach at fixed \(\eta /s(T)\)η/s(T) that incorporates initial space fluctuations generated by wounded quark model to study the hadron observables in 5.02 TeV p + Pb c...
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Article
Open Access90-gene signature assay for tissue origin diagnosis of brain metastases
Brain metastases (BM) are the most common intracranial tumors. 2–14% of BM patients present with unknown primary site despite intensive evaluations. This study aims to evaluate the performance of a 90-gene exp...
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Article
Open AccessRobot-assisted esophagectomy (RAE) versus conventional minimally invasive esophagectomy (MIE) for resectable esophageal squamous cell carcinoma: protocol for a multicenter prospective randomized controlled trial (RAMIE trial, robot-assisted minimally invasive Esophagectomy)
Currently, there are three main surgical approaches for resectable esophageal cancer: open transthoracic esophagectomy (OTE), conventional minimally invasive esophagectomy (MIE) and robot-assisted esophagectom...
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Article
Open AccessTrichostatin A reverses the chemoresistance of lung cancer with high IGFBP2 expression through enhancing autophagy
Insulin-like growth factor (IGF) signaling plays an important role in tumorigenesis and metastasis. Here, we analyzed insulin-like growth factor (IGF) binding protein-2 (IGFBP2) expression in 81 lung cancer pa...
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Article
Open AccessIdentification and validation of a 44-gene expression signature for the classification of renal cell carcinomas
Renal cancers account for more than 3% of all adult malignancies and cause more than 23,400 deaths per year in China alone. The four most common types of kidney tumours include clear cell, papillary, chromopho...
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Article
Open AccessReduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway
miR-3127-5p is a primate-specific miRNA which is down-regulated in recurrent NSCLC tissue vs. matched primary tumor tissue (N = 15) and in tumor tissue vs. normal lung tissue (N = 177). Reduced miR-3127-5p expres...
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Article
Open AccessEarly results after surgical treatment of left Ventricular Aneurysm
Left ventricular aneurysm (LVA) is a serious complication of myocardial infarction and reduces the chances of survival. Controversy still exists regarding the optimal surgical technique for LVA repair. We anal...
