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  1. No Access

    Article

    Design, synthesis and biological evaluation of isoxazole-containing biphenyl derivatives as small-molecule inhibitors targeting the programmed cell death-1/ programmed cell death-ligand 1 immune checkpoint

    Monoclonal antibodies targeting the programmed cell death-1/ programmed cell death-ligand 1 (PD-1/PD-L1) immune checkpoint have achieved enormous success in cancer immunotherapy. But the antibody-based immunot...

    Peiyu Zhu, Jian Zhang, Yifei Yang, Lixun Wang, **pei Zhou… in Molecular Diversity (2022)

  2. Article

    Gastrointestinal Symptoms Onset in COVID-19 Patients in Wuhan, China

    Early detection is critical in limiting the spread of 2019 novel coronavirus (COVID-19). Although previous data revealed characteristics of GI symptoms in COVID-19, for patients with only GI symptoms onset, th...

    ** An, Hongbin Chen, Haixia Ren, Juan Su, Mengyao Ji… in Digestive Diseases and Sciences (2021)

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    Article

    Preparation of hemoglobin (Hb)-imprinted poly(ionic liquid)s via Hb-catalyzed eATRP on gold nanodendrites

    Hemoglobin (Hb)-imprinted poly(ionic liquid)s (HIPILs) were prepared on the surface of Au electrode modified with gold nanodendrites (Au/ND/HIPILs). HIPILs were synthesized with 1-vinyl-3-propyl imidazole sulf...

    Yue Sun, Xuewei Feng, **g Hu, Shuang Bo… in Analytical and Bioanalytical Chemistry (2020)

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    Article

    Identification of novel MEK1 inhibitors by pharmacophore and docking based virtual screening

    Mitogen-activated protein kinase/mitogen-activated protein kinase kinase1 plays a key role in the Ras/Raf/MEK/ERK signaling pathway associated with cell growth, differentiation and development. In an effort to...

    Fangxia Zou, Yifei Yang, Tianfang Ma, Jiayue **… in Medicinal Chemistry Research (2017)

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    Article

    Combined pharmacophore models as virtual screening protocol against BRD4(1) inhibitor

    Bromodomain-containing protein is involved in many essential cellular processes, such as chromosomes for cell cycle progression, cellular viability and embryonic stem cell regulation, which plays a significan...

    Yifei Yang, Fangxia Zou, Leilei Zhao, Yulan Cheng… in Medicinal Chemistry Research (2016)