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  1. Article

    Open Access

    Isoform specific FBXW7 mediates NOTCH1 Abruptex mutation C1133Y deregulation in oral squamous cell carcinoma

    Our group previously identified that the NOTCH1 Abruptex domain contains the most mutations in Chinese OSCC patients, including a hotspot mutation (C1133Y). FBXW7 is an E3 ubiquitin ligase that regulates a net...

    Yang Zheng, An Song, Chundi Wang, Wei Zhang, Dong Liang, Xu Ding… in Cell Death & Disease (2020)

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  2. No Access

    Article

    O-GlcNAcylation modulates liquid–liquid phase separation of SynGAP/PSD-95

    Liquid–liquid phase separation (LLPS) of SynGAP and PSD-95, two abundant proteins that interact in the postsynaptic density (PSD) of neurons, has been implicated in modulating SynGAP PSD enrichment in excitato...

    Pinou Lv, Yifei Du, Changdong He, Luxin Peng, **nyue Zhou, Yi Wan… in Nature Chemistry (2022)