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Article
Open AccessMiR-876-5p modulates head and neck squamous cell carcinoma metastasis and invasion by targeting vimentin
Local or distant metastasis remains the main course of death in head and neck squamous cell carcinoma (HNSCC) patients. MicroRNAs (miRNAs) have been implicated in metastasis of HNSCC, but the mechanisms of the...
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Article
Open AccessIsoform specific FBXW7 mediates NOTCH1 Abruptex mutation C1133Y deregulation in oral squamous cell carcinoma
Our group previously identified that the NOTCH1 Abruptex domain contains the most mutations in Chinese OSCC patients, including a hotspot mutation (C1133Y). FBXW7 is an E3 ubiquitin ligase that regulates a net...
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Article
Open AccessAKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformations
Venous malformations (VMs), most of which associated with activating mutations in the endothelial cells (ECs) tyrosine kinase receptor TIE2, are characterized by dilated and immature veins with scarce smooth m...
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Article
Open AccessImmunotherapy with heat shock protein 96 to treat gliomas
Heat shock protein 96 (gp96) is a highly conserved protein in the endoplasmic reticulum. The functions of gp96 include promoting the oncogenesis and progression of glioma. In addition, tumor-derived gp96 can a...
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Article
Open AccessHuman amnion-derived mesenchymal stem cells promote osteogenic differentiation of lipopolysaccharide-induced human bone marrow mesenchymal stem cells via ANRIL/miR-125a/APC axis
Periodontitis is a chronic inflammatory disease inducing the absorption of alveolar bone and leading to tooth loss. Human amnion-derived mesenchymal stem cells (HAMSCs) have been used for studying inflammatory...
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Article
Open AccessMorphometric analysis of paired fibula and mandible for optimal fibular mandibular reconstruction in a Chinese population
To analyze the morphology of paired fibula and mandible aiming to choose optimal fibular segments for mandibular reconstruction in a Chinses population. A total of 118 cases of paired mandible and fibula was c...
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Article
Open AccessWhat is nursing professionalism? a concept analysis
Nursing professionalism plays an important role in clinical nursing. However, a clear conceptual understanding of nursing professionalism is lacking.
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Article
Open AccessThe development of evaluation scale of the patient satisfaction with telemedicine: a systematic review
Since the outbreak of the COVID-19 pandemic, telemedicine become more and more popular, patients attempt to use telemedicine to meet personal medical needs. Patient satisfaction is a key indicator of insight i...
