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  1. Article

    Open Access

    LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway

    LZTFL1 is a tumor suppressor located in chromosomal region 3p21.3 that is deleted frequently and early in various cancer types including the kidney cancer. However, its role in kidney tumorigenesis remains unk...

    Jun Lu, Liang-min Fu, Yun Cao, Yong Fang, Jia-zheng Cao, Yi-hui Pan in Oncogene (2023)

  2. Article

    Open Access

    Positive feedback regulation of lncRNA PVT1 and HIF2α contributes to clear cell renal cell carcinoma tumorigenesis and metastasis

    Long noncoding RNAs (lncRNAs) have been reported to exert important roles in tumors, including clear cell renal cell carcinoma (ccRCC). PVT1 is an important oncogenic lncRNA which has critical effects on onset...

    Ming-xiao Zhang, Li-zhen Zhang, Liang-min Fu, Hao-hua Yao, Lei Tan, Zi-hao Feng in Oncogene (2021)

  3. No Access

    Article

    COL11A1 activates cancer-associated fibroblasts by modulating TGF-β3 through the NF-κB/IGFBP2 axis in ovarian cancer cells

    Ovarian cancer has a unique tumor microenvironment (TME) that enables cancer-associated fibroblasts (CAFs) to interact with cellular and matrix constituents and influence tumor development and migration into t...

    Yi-Hui Wu, Yu-Fang Huang, Tzu-Hao Chang, Chien-Chin Chen, Pei-Ying Wu in Oncogene (2021)