Skip to main content

and
  1. Article

    Open Access

    DNA nicks induce mutational signatures associated with BRCA1 deficiency

    Analysis of human cancer genome sequences has revealed specific mutational signatures associated with BRCA1-deficient tumors, but the underlying mechanisms remain poorly understood. Here, we show that one-ended D...

    Yi-Li Feng, Qian Liu, Ruo-Dan Chen, Si-Cheng Liu, Zhi-Cheng Huang in Nature Communications (2022)