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  1. No Access

    Article

    Coenzyme Q0 defeats NLRP3-mediated inflammation, EMT/metastasis, and Warburg effects by inhibiting HIF-1α expression in human triple-negative breast cancer cells

    Coenzyme Q0 (CoQ0) is a derivative quinone from Antrodia camphorata (AC) that exerts anticancer activities. This study examined the anticancer attributes of CoQ0 (0–4 µM) on inhibited anti-EMT/metastasis and NLRP...

    Hsin-Ling Yang, **-Yu Lin, Chithravel Vadivalagan, Yi-An Lin… in Archives of Toxicology (2023)

  2. Article

    Open Access

    Systemic dendrimer-drug nanomedicines for long-term treatment of mild-moderate cerebral palsy in a rabbit model

    Neuroinflammation mediated by microglia plays a central role in the pathogenesis of perinatal/neonatal brain injury, including cerebral palsy (CP). Therapeutics mitigating neuroinflammation potentially provide...

    Zhi Zhang, Yi-An Lin, Soo-Young Kim, Lilly Su, **huan Liu… in Journal of Neuroinflammation (2020)

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  3. Article

    Molecular design and synthesis of self-assembling camptothecin drug amphiphiles

    The conjugation of small molecular hydrophobic anticancer drugs onto a short peptide with overall hydrophilicity to create self-assembling drug amphiphiles offers a new prodrug strategy, producing well-defined...

    Andrew G Cheetham, Yi-an Lin, Ran Lin, Honggang Cui in Acta Pharmacologica Sinica (2017)

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