13 Result(s)
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Article
Open AccessArsenic trioxide augments immunogenic cell death and induces cGAS-STING-IFN pathway activation in hepatocellular carcinoma
The treatment of hepatocellular carcinoma (HCC) is particularly challenging due to the inherent tumoral heterogeneity and easy resistance towards chemotherapy and immunotherapy. Arsenic trioxide (ATO) has emer...
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Article
Organocatalytic aromatization-promoted umpolung reaction of imines
The umpolung functionalization of imines bears vast synthetic potential, but polarity inversion is less efficient compared with the carbonyl counterparts. Strong nucleophiles are often required to react with t...
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Article
Molecular mechanism of Rhubarb in the treatment of non-small cell lung cancer based on network pharmacology and molecular docking technology
Non-small cell lung cancer (NSCLC) is one of the leading causes of death in the world. Rhubarb, a traditional Chinese medicine, has been widely used in the treatment of inflammatory and autoimmune diseases. Th...
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Article
Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat
Vascular dementia (VaD) is the second cause of dementia after Alzheimer’s disease. Ligustilide (LIG) is one of the main active ingredients of traditional Chinese medicines, such as Angelica. Studies have reported...
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Article
CircACTR2 in macrophages promotes renal fibrosis by activating macrophage inflammation and epithelial–mesenchymal transition of renal tubular epithelial cells
The crosstalk between macrophages and tubular epithelial cells (TECs) actively regulates the progression of renal fibrosis. In the present study, we revealed the significance of circular RNA ACTR2 (circACTR2) ...
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Article
Open AccessGenome-wide identification of microRNA targets reveals positive regulation of the Hippo pathway by miR-122 during liver development
Liver development is a highly complex process that is regulated by the orchestrated interplay of epigenetic regulators, transcription factors, and microRNAs (miRNAs). Owing to the lack of global in vivo target...
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Article
Mitochondrial Genetic Diversity of the Freshwater Snail Melanoides tuberculata
According to geological history, Peninsular Malaysia and Borneo formed at different times and were once connected during Quaternary glaciations. To determine how this history has influenced phylogeography, our...
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Article
Open AccessInhibition of the JNK/MAPK signaling pathway by myogenesis-associated miRNAs is required for skeletal muscle development
Skeletal muscle differentiation is controlled by multiple cell signaling pathways, however, the JNK/MAPK signaling pathway dominating this process has not been fully elucidated. Here, we report that the JNK/MA...
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Article
Open AccessApelin attenuates the osteoblastic differentiation of aortic valve interstitial cells via the ERK and PI3-K/Akt pathways
Aortic valve calcification (AVC), which used to be recognized as a passive and irreversible process, is now widely accepted as an active and regulated process characterized by osteoblastic differentiation of a...
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Article
Analysis of Myocardial 18F-FDG Uptake by PET/CT in the Patients with Different Dialectically Classified Coronary Heart Diseases (CHD)
To quantify myocardial glucose metabolism by 18F-FDG PET/CT in patients that have coronary heart disease (CHD) according to traditional Chinese medicine classification. Ninety patients with CHD were enrolled and ...
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Article
Current Perspectives in Genetics of “Double-Hit” Lymphoma with Possible Clinical Implications
This article reviews particular subgroup of B-cell lymphoma, called “double-hit” lymphoma (DHL) because of its distinct aberrations-related genes influencing various processes such as apoptosis, differentiatio...
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Protocol
Analysis of Microdissected Cells by Two-Dimensional LC-MS Approaches
Laser capture microdissection (LCM) is a powerful tool that enables the isolation of specific cell types from tissue sections, overcoming the problem of tissue heterogeneity and contamination. We combined the ...
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Article
Electroacupuncture and Moxibustion Promote Neutrophil Apoptosis and Improve Ulcerative Colitis in Rats
The purpose of this study was to investigate the effect of electroacupuncture (EA) and moxibustion on promoting neutrophil apoptosis. A rat model of ulcerative colitis was established by immunological methods ...
