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Article
Novel Multiplexed High Throughput Screening of Selective Inhibitors for Drug-Metabolizing Enzymes Using Human Hepatocytes
Selective chemical inhibitors are critical for reaction phenoty** to identify drug-metabolizing enzymes that are involved in the elimination of drug candidates. Although relatively selective inhibitors are a...
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Article
Characterization of CYP3A5 Selective Inhibitors for Reaction Phenoty** of Drug Candidates
CYP3A is one of the most important classes of enzymes and is involved in the metabolism of over 70% drugs. While several selective CYP3A4 inhibitors have been identified, the search for a selective CYP3A5 inhi...
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Protocol
Design of Cyclic Peptides as Protein Recognition Motifs
Protein–protein interactions are ubiquitous, essential to almost all known biological processes, and offer attractive opportunities for therapeutic intervention. Linear peptide drugs, however, can be applied t...