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  1. No Access

    Article

    The Protective Effects of Riluzole on Manganese-Induced Disruption of Glutamate Transporters and Glutamine Synthetase in the Cultured Astrocytes

    Chronic exposure to excessive manganese (Mn) can lead to manganism, a type of neurotoxicity accomplished with extracellular glutamate (Glu) accumulation. To investigate this accumulation, this study focused on...

    Yu Deng, Zhaofa Xu, Bin Xu, Donghui Xu, Yawen Tian… in Biological Trace Element Research (2012)

  2. No Access

    Article

    G0/G1 Phase Arrest and Apoptosis Induced by Manganese Chloride on Cultured Rat Astrocytes and Protective Effects of Riluzole

    Occupational or environmental exposure to excessive Mn would cause manganism, which is resembled Parkinson disease. However, the mechanism underlying manganism is still unknown. It had been documented that ast...

    Yu Deng, Donghui Xu, Bin Xu, Zhaofa Xu, Yawen Tian… in Biological Trace Element Research (2011)

  3. No Access

    Article

    Excitotoxicity in Rat’s Brain Induced by Exposure of Manganese and Neuroprotective Effects of Pinacidil and Nimodipine

    Manganese (Mn) is an essential trace element for humans. However, manganism would be caused by excessive Mn. The mechanisms underlying excitotoxicity induced by manganism are poorly understood. As it is known ...

    Yu Deng, Zhaofa Xu, Bin Xu, YaWen Tian, **aoqiang Deng… in Biological Trace Element Research (2009)