24 Result(s)
within
Yaqiang **e
Life Sciences
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Article
Open AccessThree-dimensional chromatin reorganization regulates B cell development during ageing
The contribution of three-dimensional genome organization to physiological ageing is not well known. Here we show that large-scale chromatin reorganization distinguishes young and old bone marrow progenitor (p...
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Article
Open AccessHMGB1 prefers to interact with structural RNAs and regulates rRNA methylation modification and translation in HeLa cells
High-mobility group B1 (HMGB1) is both a DNA binding nuclear factor modulating transcription and a crucial cytokine that mediates the response to both infectious and noninfectious inflammation such as autoimmu...
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Article
Spatiotemporal control of RNA metabolism and CRISPR–Cas functions using engineered photoswitchable RNA-binding proteins
RNA molecules perform various crucial roles in diverse cellular processes, from translating genetic information to decoding the genome, regulating gene expression and catalyzing chemical reactions. RNA-binding...
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Article
Open AccessSmoldering charcoal detection in forest soil by multiple CO sensors
Cleaning up residual fires is an important part of forest fire management to avoid the loss of forest resources caused by the recurrence of a residual fire. Existing residual fire detection equipment is mainly...
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Chapter and Conference Paper
Breeding and Efficiency Evaluation of a High-Yielding Cellobiohydrolase Strain
Objective: Energy and environmental issues are one of the most severe challenges for human survival and development in the 21st century. Therefore, the global interest in develo** lignocellulosic biomass res...
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Chapter and Conference Paper
High-Yielding Laccase Strain Breeding and Optimization of Fermentation Conditions
Objective: Laccase is a copper-containing polyphenol oxidase, which is widely used in papermaking, food, environmental treatment and bioenergy. At present, white rot fungi is one of the important laccase-produ...
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Chapter and Conference Paper
Screening and Efficacy Evaluation of High-Yielding Manganese Peroxidase Strain
Background: Lignocellulose resources are abundant, but the utilization of lignocellulose is seriously hindered by the existence of lignin. Microorganisms rely on lignin-degrading enzymes to degrade lignin effi...
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Chapter and Conference Paper
Extraction, Composition Analysis and Blood Lipid Lowering Activity of Rana chensinensis Ovum Oil
Objective: Rana chensinensis ovum is one of the main by-products of Rana chensinensis oil, which has a large annual output but has not been fully utilized. Research shows that it contains a variety of bioactive s...
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Chapter and Conference Paper
Research on Craft Optimization of Wheat Straw Pretreatment
Background: Lignocellulose resources are abundant, but the utilization rate is very low, and wheat straw is one of them. The main reason is that the compact structure of lignin limits the conversion and utiliz...
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Article
KCNQ1OT1 promotes genome-wide transposon repression by guiding RNA–DNA triplexes and HP1 binding
Transposon (de)repression and heterochromatin reorganization are dynamically regulated during cell fate determination and are hallmarks of cellular senescence. However, whether they are sequence specifically r...
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Article
Open AccessscPCOR-seq enables co-profiling of chromatin occupancy and RNAs in single cells
Cell-to-cell variation in gene expression is a widespread phenomenon, which may play important roles in cellular differentiation, function, and disease development1–9. Chromatin is implicated in contributing to t...
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Article
The importance of conditionally rare taxa for the assembly and interaction of fungal communities in mangrove sediments
The fungal communities provide the nutrients and drive the cycles of elements in nature, and the rare fungal taxa are proved to be crucial for these communities in many environments. However, the ecological fu...
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Article
Enhanced genome editing to ameliorate a genetic metabolic liver disease through co-delivery of adeno-associated virus receptor
Genome editing through adeno-associated viral (AAV) vectors is a promising gene therapy strategy for various diseases, especially genetic disorders. However, homologous recombination (HR) efficiency is extreme...
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Article
Three-dimensional facial-image analysis to predict heterogeneity of the human ageing rate and the impact of lifestyle
Not all individuals age at the same rate. Methods such as the ‘methylation clock’ are invasive, rely on expensive assays of tissue samples and infer the ageing rate by training on chronological age, which is u...
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Article
Characterization of functional transposable element enhancers in acute myeloid leukemia
Transposable elements (TEs) have been shown to have important gene regulatory functions and their alteration could lead to disease phenotypes. Acute myeloid leukemia (AML) develops as a consequence of a series...
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Article
Open AccessMidgut microbiota diversity of potato tuber moth associated with potato tissue consumed
The potato tuber moth (PTM), Phthorimaea operculella (Zeller), is a worldwide pest that feeds on both the leaves and tubers of potato plants. PTM larvae can digest leaves, or tubers, resulting in serious damage t...
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Article
Open AccessGenome-wide identification of AGO18b-bound miRNAs and phasiRNAs in maize by cRIP-seq
Argonaute proteins (AGOs) are important players in the regulation of plant development by directing sRNAs to target mRNAs. In maize (Zea mays), AGO18b is a tassel-enriched and grass-specific AGO. Previous studies...
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Article
Volatile allelochemicals of Chenopodium ambrosioides L. induced mitochondrion-mediated Ca2+-dependent and Caspase-dependent apoptosis signaling pathways in receptor plant cells
This study aims to explain the mechanism of action of allelochemical effect of Chenopodium ambrosioides L. volatile oil on mitochondrial characteristics of receptor plants.
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Article
RNAi as a tool to control the sex ratio of mouse offspring by interrupting Zfx/Zfy genes in the testis
The objective of this study was to explore a novel method to alter the sex-ratio balance of mouse offspring by silencing the paralogous genes Zfx/Zfy (Zinc finger X/Y-chromosomal transcription factor gene) during...
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Article
Biogas slurry use as N fertilizer for two-season Zizania aquatica Turcz. in China
The development of ecological circular agriculture has been highly encouraged by the Chinese government to recycle agricultural wastes, reduce mineral fertilizer input, and protect the environment. Biogas slur...
