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Sleep-mediated regulation of reward circuits: implications in substance use disorders

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  1. Article

    Open Access

    Neural deficits in a mouse model of PACS1 syndrome are corrected with PACS1- or HDAC6-targeting therapy

    PACS1 syndrome is a neurodevelopmental disorder (NDD) caused by a recurrent de novo missense mutation in PACS1 (p.Arg203Trp (PACS1R203W)). The mechanism by which PACS1R203W causes PACS1 syndrome is unknown, and n...

    Sabrina Villar-Pazos, Laurel Thomas, Yunhan Yang, Kun Chen… in Nature Communications (2023)

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  2. Article

    Cocaine-Induced Synaptic Alterations in Thalamus to Nucleus Accumbens Projection

    Exposure to cocaine induces addiction-associated behaviors partially through remodeling neurocircuits in the nucleus accumbens (NAc). The paraventricular nucleus of thalamus (PVT), which projects to the NAc mo...

    Peter A Neumann, Yicun Wang, Yi** Yan, Yao Wang… in Neuropsychopharmacology (2016)

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  3. Article

    Cocaine-Induced Membrane Adaptation in the Central Nucleus of Amygdala

    Exposure to drugs of abuse lead to both rewarding effects and the subsequent development of negative affects. The progressive dysregulation of both processes is thought to critically contribute to the addictiv...

    Bo Chen, Yao-Ying Ma, Yao Wang, **usong Wang, Oliver M Schlüter… in Neuropsychopharmacology (2013)

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