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Article
Design and synthesis of novel factor XIa Inhibitors with bicyclic isoquinoline and naphthalene fragments
FXIa has emerged as a promising therapeutic target for treating thrombotic diseases. With the aim to replace the aniline motif of asundexian with novel P2’ fragments, bicyclic isoquinoline and naphthalene ring...
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Article
Open AccessEffects of long-term PM2.5 exposure on metabolic syndrome among adults and elderly in Guangdong, China
We aimed to explore the association between long-term exposure to particulate matter ≤ 2.5 µm (PM2.5) and metabolic syndrome (MetS) and its components including fasting blood glucose (FBG), blood pressure, trigly...
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Article
Open AccessTrends and external causes of traumatic brain injury and spinal cord injury mortality in south China, 2014–2018: an ecological study
The epidemiological evidence of traumatic brain injury (TBI) and spinal cord injury (SCI) mortality in mainland China is lacking. We aimed to assess the trends of TBI and SCI mortality, and their association w...
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Article
Open AccessAge-standardized mortality, disability-adjusted life-years and healthy life expectancy in different cultural regions of Guangdong, China: a population-based study of 2005–2015
Guangdong province is dominated by three cultural regions: Canton, Hakka and Hoklo. However, little is known about the disease burden within these regions, particularly because different population,environment...
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Article
Author Correction: Regional variation limits applications of healthy gut microbiome reference ranges and disease models
In the version of this article originally published, in the sentence “Applying the same approach to obesity (Fig. 2b), MetS (Fig. 2c) and fatty liver (Fig. 2d) yielded similar results,” two figure panels were ...
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Article
Regional variation limits applications of healthy gut microbiome reference ranges and disease models
Dysbiosis, departure of the gut microbiome from a healthy state, has been suggested to be a powerful biomarker of disease incidence and progression1–3. Diagnostic applications have been proposed for inflammatory ...
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Article
Open AccessLinking gut microbiota, metabolic syndrome and economic status based on a population-level analysis
The metabolic syndrome (MetS) epidemic is associated with economic development, lifestyle transition and dysbiosis of gut microbiota, but these associations are rarely studied at the population scale. Here, we...
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Article
Regional, age and respiratory-secretion-specific prevalence of respiratory viruses associated with asthma exacerbation: a literature review
Despite increased understanding of how viral infection is involved in asthma exacerbations, it is less clear which viruses are involved and to what extent they contribute to asthma exacerbations. Here, we soug...
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Article
Suppression of phosphorylated MAPK and caspase 3 by carbon dioxide
Although CO2 is produced during the oxidation of different substrates in all types of cells, the role of this gas in the regulation of cellular function is not clearly understood. Since changes in several signal ...
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Article
Open AccesssPAGM: inferring subpathway activity by integrating gene and miRNA expression-robust functional signature identification for melanoma prognoses
MicroRNAs (miRNAs) regulate biological pathways by inhibiting gene expression. However, most current analytical methods fail to consider miRNAs, when inferring functional or pathway activities. In this study, ...
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Article
Open AccessLow-frequency ultrasound-induced VEGF suppression and synergy with dendritic cell-mediated anti-tumor immunity in murine prostate cancer cells in vitro
High tumor vascular endothelial growth factor (VEGF) levels are associated with poor treatment outcomes in prostate cancer (PCa), and immune deficiency in the PCa microenvironment, especially suppression of de...
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Chapter
Role of Skeletal Muscle Angiogenesis in Peripheral Artery Disease
Peripheral artery disease is a major circulatory disorder, which is characterized by obstruction of arteries mainly due to atherosclerosis and thrombosis, leading to reduced blood supply and ischemia in the hi...
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Chapter
Regulation of Membrane Na+-K+ ATPase in Health and Disease
Na+-K+ ATPase is primarily localized in the plasma membrane and occurs in the form of α-subunits (α-1, -2, and -3 isoforms) and β-subunits (β-1 and -2 isoforms) mainly. The inhibition of this enzyme by cardiac gl...
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Article
Open AccessEstimation of cancer burden in Guangdong Province, China in 2009
Surveying regional cancer incidence and mortality provides significant data that can assist in making health policy for local areas; however, the province- and region-based cancer burden in China is seldom rep...
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Article
Effect of the Shenfu Injection Combined with Early Goal-Directed Therapy on Organ Functions and Outcomes of Septic Shock Patients
Shenfu injection (SFI) derived from traditional Chinese medicine has been widely used in cardiovascular diseases. The objective of this study was to determine the effect of SFI and conventional early goal-dire...
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Article
Open AccessDramatic escalation in metabolic syndrome and cardiovascular risk in a Chinese population experiencing rapid economic development
Metabolic syndrome (MetSyn) increases the incidence of cardiovascular disease. Information on changes in prevalence of MetSyn in develo** countries is limited. This study aims to compare MetSyn prevalence an...
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Article
Hemodiafiltration Combined with Resin-Mediated Absorption as a Therapy for Hyperlipidemic Acute Pancreatitis
The aim of this study is to investigate whether hemodiafiltration combined with resin-mediated absorption is a better therapy for hyperlipidemic acute pancreatitis. Patients (n = 67) with acute pancreatitis treat...
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Article
Efficacy of Various Combined Blood Purification Techniques for Treating Patients with Non-viral Acute Liver Failure
We sought to study the clinical efficacy of various combined blood purification techniques in patients with non-viral acute liver failure complicated by multiple organ dysfunction syndrome (MODS). For this pur...
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Chapter
Abnormalities in ATP Production and Utilization in Diabetic Cardiomyopathy
For the heart to produce mechanical force, two cellular components are essential: myofibrils, which are responsible for generating contractile activity, and mitochondria, which provide most of the required ene...
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Chapter
Nutritional Management of Cardiovascular Complications Caused by Diabetes
Several lines of epidemiological, experimental, and clinical evidence have demonstrated a correlation between diet and increased risk of develo** diabetes-induced cardiovascular complications. The increased ...
