1,198 Result(s)
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Yan**g Tang
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Article
Vesicle-associated membrane protein 8 knockdown exerts anti-proliferative, pro-apoptotic, anti-autophagic, and pro-ferroptotic effects on colorectal cancer cells by inhibition of the JAK/STAT3 pathway
Vesicle-associated membrane protein 8 (VAMP8), a soluble n-ethylmaleimide-sensitive factor receptor protein, acts as an oncogenic gene in the progression of several malignancies. Nevertheless, the roles and me...
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The high-temperature oxidation behavior and mechanism in a powder metallurgy Ni-based superalloy featuring δ-Nb3Al addition
Incorporating strengthening phase with a higher thermal stability than traditional L12-ordered Ni3Al phase offers a promising avenue for develo** the next-generation Ni-based superalloys. In this study, a powde...
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Flexible Clustering with a Sparse Mixture of Generalized Hyperbolic Distributions
Robust clustering of high-dimensional data is an important topic because clusters in real datasets are often heavy-tailed and/or asymmetric. Traditional approaches to model-based clustering often fail for high...
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Open AccessDesigning a highly efficient type III polyketide whole-cell catalyst with minimized byproduct formation
Polyketide synthases (PKSs) are classified into three types based on their enzyme structures. Among them, type III PKSs, catalyzing the iterative condensation of malonyl-coenzyme A (CoA) with a CoA-linked star...
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Enhanced tribology properties induced by eutectic microstructure strengthening and in-situ reinforcing in laser cladded composite coating
With the development of laser deposition technology, the Invar alloy matrix materials is a kind of potential laser deposited coating because of low expansion coefficient, which is favor to decrease the residua...
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Open AccessSex-related differences in left atrial substrate among patients with atrial fibrillation: evidence from high-density voltage map**
There is sufficient evidence that women with atrial fibrillation (AF) have a greater symptom burden than men with AF and are more likely to experience recurrence after catheter ablation. However, the mechanism...
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Prevalence and associated factors of low bone mineral density in people living with HIV: a cross-sectional study
This study examined low bone mineral density (BMD) prevalence and associated factors among Chinese people living with HIV (PLWH), uncovering a persistent high BMD risk in older individuals, even after adjustin...
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Development of a nine-variant reference material panel to standardize cell-free DNA detection
Detection of specific gene mutations in cell-free DNA (cfDNA) serves as a valuable cancer biomarker and is increasingly being explored as an appealing alternative to tissue-based methods. However, the lack of ...
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Article
Epstein-Barr virus causes vascular abnormalities in epithelial malignancies through upregulating ANXA3-HIF-1α-VEGF pathway
Angiogenesis is one of the characteristics of malignant tumors, and persistent generation of abnormal tumor blood vessels is an important factor contributing to tumor treatment resistance. Epstein-Barr virus (...
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Frequency spectrum prediction model of broaching process using theoretical cutting force time history
The amplitude of tooth passing frequency in frequency spectrum is an important indicator to judge machining quality and tool wear. In comparison to the amplitude of tooth passing frequency in acceleration spec...
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Modeling of cutting force in micro-milling considering asymmetric tool wear
The asymmetric tool wear caused by the tool runout significantly affects the cutting force in micro-milling. In this study, an improved cutting force model considering asymmetric tool wear is constructed for p...
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Research on digital twin monitoring system for hot stam**
Hot stam** of high-strength steel plays an increasingly important role as the demand for automotive lightweighting increases. However, the existing hot stam** process faces challenges such as a lack of dig...
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Article
Open AccessA single-cell sequence analysis of mouse subcutaneous white adipose tissue reveals dynamic changes during weaning
Adipose tissue development begins in the fetal period, and continues to expand after birth. Dysregulation of adipose tissue during weaning may predispose individuals to lifelong metabolic disorders. However, t...
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Stability analysis and stabilization of semi-Markov jump linear systems with unavailable sojourn-time information
This study addresses the stability and stabilization problems of discrete-time semi-Markov jump linear systems (S-MJLSs) with unavailable sojourn-time information. The sojourn-time probability mass functions (...
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Correction to: Impact of digital economy on ecological resilience of resource‑based cities: spatial spillover and mechanism
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Open AccessPatients with ASPSCR1-TFE3 fusion achieve better response to ICI based combination therapy among TFE3-rearranged renal cell carcinoma
TFE3-rearranged renal cell carcinoma (TFE3-rRCC) is a rare but highly heterogeneous renal cell carcinoma (RCC) entity, of which the clinical treatment landscape is largely undefined. This study aims to evaluate a...
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Open AccessAssessing the efficiency of eligibility criteria for low-dose computed tomography lung screening in China according to current guidelines
Evidence from observational studies indicates that lung cancer screening (LCS) guidelines with high rates of lung cancer (LC) underdiagnosis, and although current screening guidelines have been updated and eli...
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A Ca-substituted air-stable layered oxide cathode material with facilitated phase transitions for high-performance Na-ion batteries
Cost-efficient and high-performance cathodes play a crucial role in the advancement of grid-scale sodium-ion batteries (SIBs). As promising high-capacity cathode materials for SIBs, O3-type Na-based layered trans...
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Open AccessDel Nido cardioplegia versus cold blood cardioplegia in adult cardiac surgery: a meta-analysis of randomized clinical trials
Systematic evaluation of the safety of del Nido cardioplegia compared to cold blood cardioplegia in adult cardiac surgery.
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Open AccessThe impact of PD-1 inhibitors on prognosis in unresectable hepatocellular carcinoma treated with TACE and lenvatinib: a retrospective study
Our aim was to explore whether programmed death receptor-1 (PD-1) inhibitors would improve the prognosis of unresectable hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE) plus ...
