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    Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis

    Sphingomyelin (SM) has key roles in modulating mammalian membrane properties and serves as an important pool for bioactive molecules. SM biosynthesis is mediated by the sphingomyelin synthase (SMS) family, com...

    Kexin Hu, Qing Zhang, Yang Chen, **tong Yang… in Nature Structural & Molecular Biology (2024)