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  1. No Access

    Article

    Role of Exercise on Inflammation Cytokines of Neuropathic Pain in Animal Models

    Neuropathic pain (NP) resulting from a lesion or disease of the somatosensory system can lead to loss of function and reduced life quality. Neuroinflammation plays a vital role in the development and maintenan...

    Ya-Nan Zheng, Yi-Li Zheng, Xue-Qiang Wang, Pei-Jie Chen in Molecular Neurobiology (2024)

  2. No Access

    Article

    Doublecortin-Expressing Neurons in Human Cerebral Cortex Layer II and Amygdala from Infancy to 100 Years Old

    A cohort of morphologically heterogenous doublecortin immunoreactive (DCX +) “immature neurons” has been identified in the cerebral cortex largely around layer II and the amygdala largely in the paralaminar nu...

    Ya-Nan Li, Dan-Dan Hu, **ao-Lu Cai, Yan Wang, Chen Yang… in Molecular Neurobiology (2023)

  3. Article

    Open Access

    Kai-**n-San Inhibits Tau Pathology and Neuronal Apoptosis in Aged SAMP8 Mice

    Alzheimer’s disease (AD) is an age-related neurological disorder. Currently, there is no effective cure for AD due to its complexity in pathogenesis. In light of the complex pathogenesis of AD, the traditional...

    Ya-Nan Jiao, **g-Sheng Zhang, Wen-Jun Qiao, Shu-Yu Tian… in Molecular Neurobiology (2022)

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  4. No Access

    Article

    Interleukin-13 Affects the Recovery Processes in a Mouse Model of Hemorrhagic Stroke with Bilateral Tibial Fracture

    As one form of stroke, intracerebral hemorrhage (ICH) is a fatal cerebrovascular disease, which has high morbidity and mortality and lacks effective medical treatment. Increased infiltration of inflammatory cy...

    Ya’nan Yan, Cheng Gao, Guang Chen, Xueshi Chen, Yanglin Wu… in Molecular Neurobiology (2022)

  5. No Access

    Article

    Restraint Stress Delays the Recovery of Neurological Impairments and Exacerbates Brain Damages through Activating Endoplasmic Reticulum Stress-mediated Neurodegeneration/Autophagy/Apopotosis post Moderate Traumatic Brain Injury

    Based on accumulating evidence, patients recovering from mild and moderate traumatic brain injury (TBI) often experience increased sensitivity to stressful events. However, few studies have assessed on the eff...

    Cheng Gao, Xueshi Chen, Heng Xu, Hanmu Guo, Lexin Zheng… in Molecular Neurobiology (2022)

  6. No Access

    Article

    Associations of Sleep Characteristics with Cerebrospinal Fluid sTREM2 in Cognitively Normal Older Adults: the CABLE Study

    As brain insults, sleep disorders could enhance microglial activation and aggravate neuroinflammation. Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) serves as a...

    He-Ying Hu, Ling-Zhi Ma, Hao Hu, Yan-Lin Bi, Ya-Hui Ma… in Neurotoxicity Research (2021)

  7. No Access

    Article

    Serum Calcium Predicts Cognitive Decline and Clinical Progression of Alzheimer’s Disease

    Relationship between serum calcium and Alzheimer’s disease (AD) remains unclear. The aim of this study is to test whether serum calcium is associated with other AD-associated biomarkers and could predict clini...

    Ling-Zhi Ma, Zi-Xuan Wang, Zuo-Teng Wang, **ao-He Hou… in Neurotoxicity Research (2021)

  8. No Access

    Article

    Sepsis and Cerebral Dysfunction: BBB Damage, Neuroinflammation, Oxidative Stress, Apoptosis and Autophagy as Key Mediators and the Potential Therapeutic Approaches

    Sepsis-associated cerebral dysfunction is complex pathophysiology, generated from primary infections that are developed elsewhere in the body. The neonates, elderly population and chronically ill and long-term...

    Ming Gu, **ang-Lin Mei, Ya-Nan Zhao in Neurotoxicity Research (2021)

  9. No Access

    Article

    Inhibiting ER Stress Weakens Neuronal Pyroptosis in a Mouse Acute Hemorrhagic Stroke Model

    Intracerebral hemorrhage (ICH) is a form of stroke, characterized by high morbidity and mortality and currently lacks specific therapy. ICH leads to endoplasmic reticulum (ER) stress, which can induce neurolog...

    Guang Chen, Cheng Gao, Ya’nan Yan, Tao Wang, Chengliang Luo… in Molecular Neurobiology (2020)

  10. No Access

    Article

    Effect of Interaction between Adenosine and Nitric Oxide on Central Nervous System Oxygen Toxicity

    The metabolism of adenosine (ADO) and nitric oxide (NO) in brain tissues is closely associated with the change of oxygen content. They have contrary effects in the onset of hyperbaric oxygen (HBO)-induced cent...

    Cheng-wei **e, Zhong-zhuang Wang, Ya-nan Zhang, Yu-liang Chen… in Neurotoxicity Research (2019)

  11. No Access

    Article

    Social Isolation During Adolescence Induces Anxiety Behaviors and Enhances Firing Activity in BLA Pyramidal Neurons via mGluR5 Upregulation

    Social isolation during the vulnerable period of adolescence contributes to the occurrence of psychiatric disorders and profoundly affects brain development and adult behavior. Although the impact of social is...

    Song Lin, **n Li, Yi-Hua Chen, Feng Gao, Hao Chen, Neng-Yuan Hu… in Molecular Neurobiology (2018)

  12. No Access

    Article

    MiR-181b Antagonizes Atherosclerotic Plaque Vulnerability Through Modulating Macrophage Polarization by Directly Targeting Notch1

    Atherosclerotic plaque vulnerability is the major cause for acute stroke and could be regulated by macrophage polarization. MicroRNA-181b (miR-181b) was involved in macrophage differential. Here, we explore wh...

    Tian-Hui An, Quan-Wei He, Yuan-Peng **a, Sheng-Cai Chen… in Molecular Neurobiology (2017)

  13. No Access

    Article

    MicroRNA-27a Promotes Inefficient Lysosomal Clearance in the Hippocampi of Rats Following Chronic Brain Hypoperfusion

    Chronic brain hypoperfusion (CBH) induces the accumulation of abnormal cellular proteins, accompanied by cognitive decline, and the autophagic-lysosomal system is abnormal in dementia. Whether CBH accounts for...

    Hui Che, Yan Yan, **ao-Hui Kang, Fei Guo, Mei-Ling Yan… in Molecular Neurobiology (2017)

  14. No Access

    Article

    5-HMF attenuates striatum oxidative damage via Nrf2/ARE signaling pathway following transient global cerebral ischemia

    Recent studies have shown 5-hydroxymethyl-2-furfural (5-HMF) has favorable biological effects, and its neuroprotection in a variety of neurological diseases has been noted. Our previous study showed that treat...

    Bai-liu Ya, Hong-fang Li, Hai-ying Wang, Fei Wu, Qing **n… in Cell Stress and Chaperones (2017)

  15. No Access

    Article

    Loss of ICA69 Potentiates Long-Lasting Hyperalgesia After Subcutaneous Formalin Injection into the Mouse Hindpaw

    Islet-cell autoantigen 69 kDa (ICA69) plays an important role in many diseases and physiological activities by forming heteromeric complexes with protein interacts with C-kinase 1 (PICK1). PICK1 is critical fo...

    Qian-Jun Li, Zhen Wang, Yong-**ng Yao, Shen-Hui **, Mei-Zi Qian… in Neurochemical Research (2015)

  16. No Access

    Article

    Neural Differentiation of Mesenchymal Stem Cells Influences Their Chemotactic Responses to Stromal Cell-Derived Factor-1α

    Mesenchymal stem cells (MSCs) are proposed as a promising source for cell-based therapies in neural disease. Although increasing numbers of studies have been devoted to the delineation of factors involved in t...

    **ao**g Xu, Guiqin **e, Ya’nan Hu, **anyang Li… in Cellular and Molecular Neurobiology (2014)

  17. No Access

    Article

    Effect of Rosuvastatin on OX40L and PPAR-γ Expression in Human Umbilical Vein Endothelial Cells and Atherosclerotic Cerebral Infarction Patients

    Atherosclerotic cerebral infarction (ACI) is characterized by extremely high fatality and disability rate. Recent studies indicate that co-stimulatory signal of tumor necrosis factor superfamily OX40/OX40L con...

    **g-Yu Zhang, Bin Liu, Ya-Nan Wang, Wei-Na Zhang… in Journal of Molecular Neuroscience (2014)

  18. No Access

    Article

    Expression of Hsp70 in the mud crab, Scylla paramamosain in response to bacterial, osmotic, and thermal stress

    Hsp70 is involved in immune responses against infectious pathogens, thermal, and osmotic stress. To understand the immune defense mechanisms of the mud crab Scylla paramamosain, genomic DNA, transcript level and ...

    Ya’nan Yang, Haihui Ye, Huiyang Huang, Shao**g Li… in Cell Stress and Chaperones (2013)

  19. No Access

    Article

    Astrocyte-Derived Sonic Hedgehog Contributes to Angiogenesis in Brain Microvascular Endothelial Cells via RhoA/ROCK Pathway After Oxygen–Glucose Deprivation

    The human adult brain possesses intriguing plasticity, including neurogenesis and angiogenesis, which may be mediated by the activated sonic hedgehog (Shh). By employing a coculture system, brain microvascular...

    Quan-Wei He, Yuan-Peng **a, Sheng-Cai Chen, Yong Wang, Ming Huang… in Molecular Neurobiology (2013)