13 Result(s)
within
Ya-Nan **a
Behavioral Sciences
Medicine/Public Health, general
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Article
Open AccessPhysical frailty, genetic predisposition, and incident dementia: a large prospective cohort study
Physical frailty and genetic factors are both risk factors for increased dementia; nevertheless, the joint effect remains unclear. This study aimed to investigated the long-term relationship between physical f...
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Article
Open AccessAnxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons
Diabetic patients receiving the antidiabetic drug metformin have been observed to exhibit a lower prevalence of anxiety disorders, yet the precise mechanism behind this phenomenon is unclear. In our study, we ...
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Article
Open AccessAssociations of cardiovascular risk factors and lifestyle behaviors with neurodegenerative disease: a Mendelian randomization study
Previous observational studies reported that midlife clustering of cardiovascular risk factors and lifestyle behaviors were associated with neurodegenerative disease; however, these findings might be biased by...
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Open AccessThe genetic architecture of fornix white matter microstructure and their involvement in neuropsychiatric disorders
The fornix is a white matter bundle located in the center of the hippocampaldiencephalic limbic circuit that controls memory and executive functions, yet its genetic architectures and involvement in brain diso...
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Article
Open AccessThe genetic architecture of human amygdala volumes and their overlap with common brain disorders
The amygdala is a crucial interconnecting structure in the brain that performs several regulatory functions, yet its genetic architectures and involvement in brain disorders remain largely unknown. We carried ...
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Open AccessModified dementia risk score as a tool for the prediction of dementia: a prospective cohort study of 239745 participants
Based on risk profiles, several approaches for predicting dementia risk have been developed. Predicting the risk of dementia with accuracy is a significant clinical challenge. The goal was to create a modified...
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Article
Open AccessAssociation between multimorbidity status and incident dementia: a prospective cohort study of 245,483 participants
Multimorbidity (the presence of two or more long-term conditions [LTCs]) was suggested to exacerbate the neuronal injuries. The impact of multimorbidity on dementia has not been fully elucidated. We aimed to i...
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Association of life course adiposity with risk of incident dementia: a prospective cohort study of 322,336 participants
Cohort studies report inconsistent associations between body mass index (BMI) and all-cause incident dementia. Furthermore, evidence on fat distribution and body composition measures are scarce and few studies...
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Article
Identifying causal genes for depression via integration of the proteome and transcriptome from brain and blood
Genome-wide association studies (GWASs) have identified numerous risk genes for depression. Nevertheless, genes crucial for understanding the molecular mechanisms of depression and effective antidepressant dru...
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Article
Open AccessTea consumption and risk of incident dementia: A prospective cohort study of 377 592 UK Biobank participants
As a widely consumed beverage, tea boasts diverse health benefits. Herein, we aimed to investigate the association between tea consumption and dementia risk. We conducted a prospective cohort study with 377 59...
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Article
Peripheral immunity is associated with the risk of incident dementia
Central immunity components especially microglia in dementia have been well studied and corresponding immunotherapy gradually caught the attention. However, few studies focused on peripheral immunity and demen...
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Article
Open AccessRisk factors for subjective cognitive decline: the CABLE study
Increasing evidences supported that subjective cognitive decline (SCD) might be a potential first symptomatic manifestation of Alzheimer’s disease (AD). The rapidly growing number of SCD individuals who seek m...
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Identification of novel drug targets for Alzheimer’s disease by integrating genetics and proteomes from brain and blood
Genome-wide association studies (GWASs) have discovered numerous risk genes for Alzheimer’s disease (AD), but how these genes confer AD risk is challenging to decipher. To efficiently transform genetic associa...
