72 Result(s)
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Medicine & Public Health
Medicine/Public Health, general
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Article
Open AccessRetraction Note: A natural food sweetener with anti-pancreatic cancer properties
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Open AccessCross-Platform Omics Prediction procedure: a statistical machine learning framework for wider implementation of precision medicine
In this modern era of precision medicine, molecular signatures identified from advanced omics technologies hold great promise to better guide clinical decisions. However, current approaches are often location-...
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Peri-prostatic adipose tissue measurements using MRI predict prostate cancer aggressiveness in men undergoing radical prostatectomy
To evaluate the effect of peri-prostatic adipose tissue (PPAT) measurements using preoperative MRI on the prediction of prostate cancer (PCa) aggressiveness in men undergoing radical prostatectomy (RP).
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Correction: Protein kinase Mζ in medial prefrontal cortex mediates depressive-like behavior and antidepressant response
Following publication of this article, the authors noted that the bands of Na-K ATPase in Figure S1B were mislabelled when selecting representative blots, and were erroneously duplicated from GluA2. However, t...
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Open AccessThe Greatwall kinase safeguards the genome integrity by affecting the kinome activity in mitosis
Progression through mitosis is balanced by the timely regulation of phosphorylation and dephosphorylation events ensuring the correct segregation of chromosomes before cytokinesis. This balance is regulated by...
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The incidence of silicone oil-related visual loss following the removal of heavy silicone oil
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Clinical and genetic characteristics of familial hypercholesterolemia patients with type 2 diabetes
Though type 2 diabetes mellitus (T2DM) is an important and independent risk factor for coronary artery disease (CAD) in the general population, the impact of T2DM on CAD in patients with familial hypercholeste...
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Protein kinase Mζ in medial prefrontal cortex mediates depressive-like behavior and antidepressant response
Neuronal atrophy and alterations of synaptic structure and function in the medial prefrontal cortex (mPFC) have been implicated in the pathogenesis of depression, but the underlying molecular mechanisms are la...
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SPAG5 promotes proliferation and suppresses apoptosis in bladder urothelial carcinoma by upregulating Wnt3 via activating the AKT/mTOR pathway and predicts poorer survival
Sperm-associated antigen 5 (SPAG5) is involved in various biological processes. However, the roles of SPAG5 in bladder urothelial carcinoma (BUC) are unknown. This study showed that upregulation of SPAG5 was d...
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Open AccessUncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects
Several preclinical studies have reported the rapid antidepressant effects of N-methyl-D-aspartate receptor (NMDAR) antagonists, although the underlying mechanisms are still unclear. Death-associated protein kina...
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Role of JMJD2B in colon cancer cell survival under glucose-deprived conditions and the underlying mechanisms
Metabolic stress is a common phenomenon in solid tumors. Compensatory mechanisms to overcome metabolic stress (glucose deprivation) are vital to tumor cell survival. The histone demethylase Jumonji domain-cont...
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Hepatitis B virus X protein promotes the development of liver fibrosis and hepatoma through downregulation of miR-30e targeting P4HA2 mRNA
Hepatitis B virus (HBV)-induced liver necrosis takes great part in liver cirrhosis progression. However, less is known about whether hepatitis B virus X protein (HBx) has effect on liver fibrosis. Here, we rep...
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Targeting HDAC3, a new partner protein of AKT in the reversal of chemoresistance in acute myeloid leukemia via DNA damage response
Resistance to cytotoxic chemotherapy drugs remains as the major cause of treatment failure in acute myeloid leukemia. Histone deacetylases (HDAC) are important regulators to maintain chromatin structure and co...
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Open AccessDisrupting G6PD-mediated Redox homeostasis enhances chemosensitivity in colorectal cancer
Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme that generates NADPH to maintain reduced glutathione (GSH), which scavenges reactive oxygen species (ROS) to protect cancer cell from oxidative damage. ...
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miR-302/367/LATS2/YAP pathway is essential for prostate tumor-propagating cells and promotes the development of castration resistance
Clinical intervention for patients with advanced prostate cancer (PCa) remains challenging due to the inevitable recurrence of castration-resistant prostate cancer (CRPC) after androgen deprivation therapy (AD...
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Testes-specific protease 50 promotes cell proliferation via inhibiting activin signaling
Testes-specific protease 50 (TSP50), a novelly identified oncogene, has the capacity to induce cell proliferation, cell invasion and tumor growth. Further studies indicated that CAGA-luc (an activin-responsive re...
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Open AccessMethamphetamine abuse impairs motor cortical plasticity and function
Exposure to addictive drugs triggers synaptic plasticity in reward-related brain regions, such as the midbrain, nucleus accumbens and the prefrontal cortex. Effects of chronic drug exposure on other brain area...
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Open AccessMeCP2, a target of miR-638, facilitates gastric cancer cell proliferation through activation of the MEK1/2–ERK1/2 signaling pathway by upregulating GIT1
Methyl-CpG binding protein 2 (MeCP2) is involved in the carcinogenesis and progression of multiple types of cancer. However, its precise role in gastric cancer (GC) and the relevant molecular mechanism remain ...
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Open AccessErratum: A natural food sweetener with anti-pancreatic cancer properties
Correction to: Oncogenesis (2016) 5, e217; doi:10.1038/oncsis.2016.28; published online 11 April 2016 Since the publication of the above article, the authors have realized that Figure 4b was incorrect. The cor...
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Open AccessThe promotion of the transformation of quiescent gastric cancer stem cells by IL-17 and the underlying mechanisms
Postoperative recurrence and metastasis have crucial roles in the poor prognosis of gastric cancer patients. Previous studies have indicated that gastric cancer originates from cancer stem cells (CSCs), and so...
