10 Result(s)
within
Y. Tokuda
Cancer Research
Oncology
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Article
Open AccessAnalysis of gene alterations of mitochondrial DNA D-loop regions to determine breast cancer clonality
It has been a challenge to determine breast cancer clonality accurately. The aim of the present study was to assess methods using formalin-fixed paraffin-embedded (FFPE) tissue to differentiate new primary tum...
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Article
Open AccessLapatinib monotherapy in patients with relapsed, advanced, or metastatic breast cancer: efficacy, safety, and biomarker results from Japanese patients phase II studies
HER2-positive metastatic breast cancer (MBC) relapsing after trastuzumab-based therapy may require continued HER2 receptor inhibition to control the disease and preserve the patients' quality-of-life. Efficacy...
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Article
Open AccessOverexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome
The purpose of the present study is to identify genes that contribute to cell proliferation or differentiation of breast cancers independent of signalling through the oestrogen receptor (ER) or human epidermal...
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Article
Effects of a structured psychiatric intervention on cancer patients' emotions and co** styles
Background. The aim of this study was to investigate the clinical effectiveness of a structured group intervention program for Japanese patients with breast cancer.
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Article
Open AccessDose escalation and pharmacokinetic study of a humanized anti-HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer
We conducted a phase I pharmacokinetic dose escalation study of a recombinant humanized anti-p185HER2 monoclonal antibody (MKC-454) in 18 patients with metastatic breast cancer refractory to chemotherapy. Three o...
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Article
Physicians' perspectives on "do-not-resuscitate" (DNR) orders
Background. The purpose of this study was to investigate physicians' perspectives on do-not-resuscitate (DNR) orders at Tokai University hospital, where a euthanasia-like accident occurred several years ago.
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Article
High-dose chemotherapy with autologous hematopoietic stem-cell transplantation in breast cancer
Since 1981 we have conducted four studies of the treatment of metastatic and postoperative high-risk breast cancer with high-dose chemotherapy supported by autologous hematopoietic stem-cell transplantation (...
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Article
In vitro and in vivo anti-tumour effects of a humanised monoclonal antibody against c-erbB-2 product
The c-erbB-2 product is thought to be a unique and useful target for antibody therapy of cancers overexpressing the c-erbB-2 gene. In vitro and in vivo anti-tumour effects of a humanised antibody against the e...
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Article
Prolonged survival of mice with human gastric cancer treated with an anti-c-ErbB-2 monoclonal antibody
A monoclonal antibody (MAb), 4D5, specifically recognising an extracellular epitope of the c-ErbB-2 protein, inhibited the growth of human gastric cancer overexpressing c-ErbB-2 severe combined immunodeficient...
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Article
Large-scale culture system of human CD4+ helper/killer T cells for the application to adoptive tumour immunotherapy
A simple method for the rapid expansion of human CD4+ T cells with both helper and killer functions was established. CD4+ T cells separated from peripheral blood mononuclear cells using immunomagnetic beads we...
