4 Result(s)
within
Xuming Deng
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessInsights into structure and activity of natural compound inhibitors of pneumolysin
Pneumolysin is the one of the major virulence factor of the bacterium Streptococcus pneumoniae. In previous report, it is shown that β-sitosterol, a natural compound without antimicrobial activity, is a potent an...
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Article
Open AccessCurcumin protects mice from Staphylococcus aureus pneumonia by interfering with the self-assembly process of α-hemolysin
α-hemolysin (Hla) is a self-assembling extracellular protein secreted as a soluble monomer by most Staphylococcus aureus strains and is an essential virulence factor for the pathogenesis of various S. aureus infe...
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Article
Open Accessβ-sitosterol interacts with pneumolysin to prevent Streptococcus pneumoniae infection
Pneumolysin is one of the major virulence factors elaborated by Streptococcus pneumoniae; this toxin is a member of the cholesterol-dependent cytolysins. Engagement of cholesterol induces the formation of a multi...
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Article
Open AccessNovel inhibitor discovery and the conformational analysis of inhibitors of listeriolysin O via protein-ligand modeling
Increasing bacterial resistance to available antibiotics makes the discovery of novel efficacious antibacterial agents a priority. A previous report showed that listeriolysin O (LLO) is a critical virulence fa...
