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  1. No Access

    Article

    GluR2 can Drive Neuroinflammation and Cognitive Impairments Following Peripherally Repeated Lipopolysaccharide Exposures

    Neuroinflammation is being increasingly recognized as a vital factor in the development of various neurological and neuropsychiatric diseases. Lipopolysaccharides (LPS), an outer membrane component of gram-neg...

    Xue He, **ao-yi Hu, **ao-yu Yin, **n-miao Wu, Qing-ren Liu… in Neurochemical Research (2024)

  2. No Access

    Article

    The Role of KDM2A and H3K36me2 Demethylation in Modulating MAPK Signaling During Neurodevelopment

    Intellectual disability (ID) is a condition characterized by cognitive impairment and difficulties in adaptive functioning. In our research, we identified two de novo mutations (c.955C>T and c.732C>A) at the KDM2...

    Zongyao Ren, Haiyan Tang, Wendiao Zhang, Minghui Guo, **gjie Cui… in Neuroscience Bulletin (2023)

  3. No Access

    Article

    Endothelial Cell–Derived Let-7c-Induced TLR7 Activation on Smooth Muscle Cell Mediate Vascular Wall Remodeling in Moyamoya Disease

    Moyamoya disease (MMD) is characterized by frequent migration and phenotypic transformation of vascular smooth muscle cells (VSMCs) in the intima layer of blood vessels. However, the underlying mechanism is un...

    **aopeng Ma, Yimin Huang, Xuejun He, … in Translational Stroke Research (2023)

  4. Article

    Open Access

    P2X7Rs: new therapeutic targets for osteoporosis

    Increasing evidence suggests that both the occurrence and progression of osteoporosis are associated with inflammation, especially in primary osteoporosis. The maintenance of skeletal homeostasis is dependent ...

    Haoyun Huang, Yu-Mei He, Miao-Miao Lin, Yanchao Wang… in Purinergic Signalling (2023)

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  5. No Access

    Article

    Long Non-Coding RNAs in Retinal Ganglion Cell Apoptosis

    Traumatic optic neuropathy or other neurodegenerative diseases, including optic nerve transection, glaucoma, and diabetic retinopathy, can lead to progressive and irreversible visual damage. Long non-coding RN...

    Ningzhi Zhang, Wenye Cao, Xuejun He, Yiqiao **ng… in Cellular and Molecular Neurobiology (2023)

  6. Article

    Open Access

    Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury

    The interaction between astrocytes and microglia plays a vital role in the damage and repair of brain lesions due to traumatic brain injury (TBI). Recent studies have shown that exosomes act as potent mediator...

    **aobing Long, **aolong Yao, Qian Jiang, Yi** Yang… in Journal of Neuroinflammation (2020)

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  7. No Access

    Article

    Disruption of Striatal-Enriched Protein Tyrosine Phosphatase Signaling Might Contribute to Memory Impairment in a Mouse Model of Sepsis-Associated Encephalopathy

    Sepsis-associated encephalopathy (SAE) is a potentially irreversible acute cognitive dysfunction with unclear mechanism. Striatal-enriched protein tyrosine phosphatase (STEP) is a brain-specific phosphatase wh...

    Man-man Zong, Hong-mei Yuan, Xue He, Zhi-qiang Zhou… in Neurochemical Research (2019)

  8. Article

    Open Access

    Neuritin Attenuates Neuronal Apoptosis Mediated by Endoplasmic Reticulum Stress In Vitro

    Neuritin is an extracellular glycophosphatidylinositol-linked protein that promotes neuronal survival, differentiation, function, and repair, but the exact mechanism of this neuroprotective effect remains uncl...

    **aokun Sun, Linzhi Dai, Hang Zhang, Xuejun He, Fandi Hou… in Neurochemical Research (2018)

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  9. No Access

    Article

    A histone deacetylase 3–dependent pathway delimits peripheral myelin growth and functional regeneration

    Screening for small-molecule epigenetic modulators identifies HDAC3 inhibitors that promote peripheral myelin repair after nerve injury in rodents.

    Xuelian He, Liguo Zhang, Luis F Queme, Xuezhao Liu, Andrew Lu… in Nature Medicine (2018)

  10. No Access

    Article

    Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination

    In this study, He et al. find that the CHARGE syndrome–related chromatin remodeler Chd7 regulates the initiation of myelination and remyelination in the CNS. Chd7 interacts with Sox10 to orchestrate the transcrip...

    Danyang He, Corentine Marie, Chuntao Zhao, Bongwoo Kim… in Nature Neuroscience (2016)

  11. No Access

    Article

    Small-animal PET demonstrates brain metabolic change after using bevacizumab in a rat model of cerebral ischemic injury

    To evaluate the effect of bevacizumab on cerebral ischemia, we used 2-deoxy-2-18F-fluoro-D-glucose (18F-FDG) small-animal positron emission tomography (PET) in the middle cerebral artery occlusion (MCAO) rat mode...

    Ying Dong, Fahuan Song, Jianjuan Ma, Xuexin He, Said Amer… in Neuroscience Bulletin (2014)

  12. No Access

    Article

    The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma

    Deficiency in Gnas, encoding the Gs protein α subunit, is sufficient to induce medulloblastoma in mice due to derepression of the Sonic hedgehog pathway.

    Xuelian He, Liguo Zhang, Ying Chen, Marc Remke, David Shih, Fanghui Lu… in Nature Medicine (2014)

  13. Article

    Open Access

    A sex-specific association of common variants of neuroligin genes (NLGN3 and NLGN4X) with autism spectrum disorders in a Chinese Han cohort

    Synaptic genes, NLGN3 and NLGN4X, two homologous members of the neuroligin family, have been supposed as predisposition loci for autism spectrum disorders (ASDs), and defects of these two genes have been identifi...

    **dan Yu, Xue He, Dan Yao, Zhongyue Li, Hui Li… in Behavioral and Brain Functions (2011)

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