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Article
Open AccessEffects of diets on risks of cancer and the mediating role of metabolites
Research on the association between dietary adherence and cancer risk is limited, particularly concerning overall cancer risk and its underlying mechanisms. Using the UK Biobank data, we prospectively investig...
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Article
Open AccessThe impact of diet, exercise, and sleep on Helicobacter pylori infection with different occupations: a cross-sectional study
Associations between Helicobacter pylori infection and lifestyle factors vary greatly by geographic location. This study aims to evaluate the prevalence of Helicobacter pylori infection in the Hunan cohort of cen...
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Article
Open AccessMulti-omics and single cell characterization of cancer immunosenescence landscape
Cellular senescence (CS) is closely related to tumor progression. However, the studies about CS genes across human cancers have not explored the relationship between cancer senescence signature and telomere le...
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Article
Three-dimensional/one-dimensional perovskite heterostructures for stable tri-state synaptic memristors
Memristors have great potential in neural network computation. Perovskite memristors exhibit excellent resistive-switching (RS) properties between high resistance state (HRS) and low resistance state (LRS) sta...
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Article
Open AccessPrognostic significance and value of further classification of lymphovascular invasion in invasive breast cancer: a retrospective observational study
To investigate the prognostic significance of lymphovascular invasion in invasive breast cancer and the value of using specific vascular endothelial markers to further classify lymphovascular invasion.
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Article
Bacteriophage protein Dap1 regulates evasion of antiphage immunity and Pseudomonas aeruginosa virulence impacting phage therapy in mice
Bacteriophages have evolved diverse strategies to overcome host defence mechanisms and to redirect host metabolism to ensure successful propagation. Here we identify a phage protein named Dap1 from Pseudomonas ae...
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Article
UBTF mediates activation of L3MBTL2 to suppress NISCH expression through histone H2AK119 monoubiquitination modification in breast cancer
Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) has been related to transcriptional inhibition and chromatin compaction. Nevertheless, the biological functions and mechanisms of L3MBTL2 are undefined i...
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Article
Preparation and characterization of a mesoporous silica-based copolymer loaded with bis(2-ethylhexyl) phosphate for the efficient separation of trace radium from natural thorium
A silica-supported copolymer loaded with bis (2-ethylhexyl) phosphate was prepared and first investigated for the separation of trace radium from natural 232Th. Results showed that the adsorbent was prepared succ...
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Article
Berth and yard scheduling optimization for a port with diagonal yard layout
The efficient operation of container ports relies on the coordination of operational problems including berth allocation and container internal transportation routing. Yard layout designs with diagonal cross l...
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Article
Open AccessS100A6 Regulates nucleus pulposus cell apoptosis via Wnt/β-catenin signaling pathway: an in vitro and in vivo study
Intervertebral disc degeneration (IDD) is a common musculoskeletal degenerative disease, which often leads to low back pain and even disability, resulting in loss of labor ability and decreased quality of life...
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Article
Life history of rotifers under temporally heterogeneous dietary sterol conditions
Herbivorous zooplankton potentially encounter temporal dietary heterogeneity in sterol, an essential group of lipids, over short or long time scales. There are a few studies showing that dietary sterol fluctua...
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Article
Mediating role of root-exuded secondary metabolites in intraspecific interactions with Haloxylon ammodendron
Root exudates are pivotal in soil carbon and nutrient cycling, enhancing nutrient availability and plant resource utilization efficiency under stress. Despite challenges in obtaining accurate soil-borne signal...
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Article
GluR2 can Drive Neuroinflammation and Cognitive Impairments Following Peripherally Repeated Lipopolysaccharide Exposures
Neuroinflammation is being increasingly recognized as a vital factor in the development of various neurological and neuropsychiatric diseases. Lipopolysaccharides (LPS), an outer membrane component of gram-neg...
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Article
HSP70 protects PC12 cells against TBHP-induced apoptosis and oxidative stress by activating the Nrf2/HO-1 signaling pathway
HSP70 exhibits neuroprotective, antioxidant, and anti-apoptotic properties, which are crucial in preventing spinal cord injury (SCI) induced by oxidative stress and apoptosis. In this study, we assessed the po...
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Article
Open AccessPD-1 blockade immunotherapy as a successful rescue treatment for disseminated adenovirus infection after allogeneic hematopoietic stem cell transplantation
Disseminated adenovirus infection is a complication with a relatively high mortality rate among patients undergoing hematopoietic stem cell transplantation. The low efficacy and poor availability of current tr...
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Article
Open AccessCellular communication network factor 1 promotes retinal leakage in diabetic retinopathy via inducing neutrophil stasis and neutrophil extracellular traps extrusion
Diabetic retinopathy (DR) is a major cause of blindness and is characterized by dysfunction of the retinal microvasculature. Neutrophil stasis, resulting in retinal inflammation and the occlusion of retinal mi...
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Article
Correction to: Changing regularity of plant and insect community characteristics due to pest outbreaks in Larix principis‑rupprechtii plantations
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Article
Open AccessIdentification and validation of stable reference genes for RT-qPCR analyses of Kobresia littledalei seedlings
Kobreisa littledalei, belonging to the Cyperaceae family is the first Kobresia species with a reference genome and the most dominant species in Qinghai-Tibet Plateau alpine meadows. It has several resistance gen...
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Article
Numerical Simulation Study on Pressure-Relief Effect of Protective Layer Mining in Coal Seams Prone to Rockburst Hazard
Protective layer mining is an important regional measure to reduce pressure and prevent rockburst. Based on the engineering background of frequent mining earthquakes in the 203 working face below the upper pro...
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Article
Energy evolution and structural health monitoring of coal under different failure modes: An experimental study
Structural instability in underground engineering, especially in coal–rock structures, poses significant safety risks. Thus, the development of an accurate monitoring method for the health of coal–rock bodies ...
