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4 Result(s)

within Xavier Declèves Remove this filter Biomedical Engineering and Bioengineering Remove this filter Pharmacy Remove this filter

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  1. No Access

    Article

    A Minimal PBPK Model for Plasma and Cerebrospinal Fluid Pharmacokinetics of Trastuzumab after Intracerebroventricular Administration in Patients with HER2-Positive Brain Metastatic Localizations

    Dosing regimens of trastuzumab administered by intracerebroventricular (icv) route to patients with HER2-positive brain localizations remain empirical. The objectives of this study were to describe pharmacokin...

    Alicja Puszkiel, Guilhem Bousquet, Françoise Stanke-Labesque… in Pharmaceutical Research (2023)

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    Article

    Accelerating robust plausible virtual patient cohort generation by substituting ODE simulations with parameter space map**

    The generation of plausible virtual patients (VPs) is an important step in most quantitative systems pharmacology (QSP) workflows, which requires time-intensive solving of ordinary differential equations (ODEs...

    Thibaud Derippe, Sylvain Fouliard… in Journal of Pharmacokinetics and Pharmacody… (2022)

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    Article

    Double or Simple Emulsion Process to Encapsulate Hydrophilic Oxytocin Peptide in PLA-PEG Nanoparticles

    Oral drug delivery using NPs is a current strategy for poorly absorbed molecules. It offers significant improvement in terms of bioavailability. However, the encapsulation of proteins and peptides in polymeric...

    Betty Gourdon, Xavier Declèves, Jean-Manuel Péan… in Pharmaceutical Research (2018)

  4. No Access

    Article

    P-Glycoprotein Is More Efficient at Limiting Uptake than Inducing Efflux of Colchicine and Vinblastine in HL-60 Cells

    Purpose. To investigate the role of the P-glycoprotein (P-gp) drug efflux pump in the intracellular disposition of colchicine and vinblastine.

    Xavier Declèves, Olivier Chappey, Bernadette Boval… in Pharmaceutical Research (1998)