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  1. Article

    Open Access

    Cyclooxygenase inhibitors use is associated with reduced risk of esophageal adenocarcinoma in patients with Barrett’s esophagus: a meta-analysis

    Esophageal adenocarcinoma (EAC) has high mortality and is increasing in incidence. Barrett’s esophagus (BE) increases the risk for EAC. Studies have reported inconsistent findings on the association between us...

    S Zhang, X-Q Zhang, X-W Ding, R-K Yang, S-L Huang, F Kastelein… in British Journal of Cancer (2014)

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  2. No Access

    Article

    Use of monitoring levels of soluble forms of cytokeratin 18 in the urine of patients with superficial bladder cancer following intravesical Ad-IFNα/Syn3 treatment in a phase l study

    A phase l study using intravesical Ad-IFNαSyn3 for patients with bacillus Calmette-Guérin-resistant superficial bladder cancer showed a complete remission (CR) of 43% at 90 days after treatment with high level...

    W F Benedict, M Fisher, X-Q Zhang, Z Yang, M F Munsell, C N P Dinney in Cancer Gene Therapy (2014)

  3. No Access

    Article

    Direct cytotoxicity produced by adenoviral-mediated interferon α gene transfer in interferon-resistant cancer cells involves ER stress and caspase 4 activation

    Over the past several years we have obtained considerable evidence indicating that adenoviruses-expressing interferon α (Ad-IFNα) can overcome resistance to the IFNα protein itself. Since cancer cells infected...

    Z Yang, X-Q Zhang, C N P Dinney, W F Benedict in Cancer Gene Therapy (2011)

  4. No Access

    Article

    Direct gene transfer of adenoviral-mediated interferon α into human bladder cancer cells but not the bystander factors produced induces endoplasmic reticulum stress-related cytotoxicity

    We have previously shown that adenoviral-mediated interferon α (Ad-IFNα) is cytotoxic both to cells that are sensitive to recombinant interferon α (IFNα) and to cells which are resistant to IFNα. The cancer ce...

    X-Q Zhang, Z Yang, W F Benedict in Cancer Gene Therapy (2011)

  5. No Access

    Article

    Autophagy is induced by adenoviral-mediated interferon α treatment in interferon resistant bladder cancer and normal urothelial cells as a cell death protective mechanism but not by the bystander factors produced

    We have previously shown that adenoviral-mediated interferon α (Ad-IFNα) treatment is highly cytotoxic to tumor cells which are resistant to the IFNα protein. We now report that autophagy is produced after Ad-...

    X-Q Zhang, K Dunner Jr, W F Benedict in Cancer Gene Therapy (2010)

  6. No Access

    Article

    Measuring soluble forms of extracellular cytokeratin 18 identifies both apoptotic and necrotic mechanisms of cell death produced by adenoviral-mediated interferon α: possible use as a surrogate marker

    Adenoviral transduction of human bladder cancer cells with human interferon α-2b (Ad-IFN) produces cancer-specific cell death through direct and indirect mechanisms. The indirect mechanisms involve the secrete...

    M B Fisher, X-Q Zhang, D J McConkey, W F Benedict in Cancer Gene Therapy (2009)

  7. No Access

    Article

    Early RB94-produced cytotoxicity in cancer cells is independent of caspase activation or 50 kb DNA fragmentation

    RB94, which lacks the N-terminal 112 amino-acid residues of the full-length retinoblastoma protein (RB110) is a more potent inhibitor of cancer cell growth than RB110, being cytotoxic to all cancer cell lines ...

    J Zhou, X-Q Zhang, F Ashoori, D J McConkey, M A Knowles, L Dong… in Cancer Gene Therapy (2009)

  8. Article

    Open Access

    Expression of interferon-γ in human adrenal gland and kidney tumours

    It is known that interferon-γ (IFN-γ) is produced by activated T and NK lymphoid cells, mononuclear cells, and macrophage and dendritic cells. Our previous studies have shown that IFN-γ-like immunoreactivity also...

    Q Li, X-q Zhang, L Nie, G-s Chen, H Li, F Zhang, L-y Zhang… in British Journal of Cancer (2007)

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