12 Result(s)

Article

A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population

Single nucleotide polymorphisms (SNPs) in G6PC2 have been reported to be associated with fasting plasma glucose level in several populations of European descent. However, whether G6PC2 variants have a similar eff...

C. Hu, R. Zhang, C. Wang, X. Ma, C. Wang, Q. Fang, Y. Bao, K. **ang, W. Jia in Diabetologia (2009)

Article

A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population

C. Hu, R. Zhang, C. Wang, X. Ma, C. Wang, Q. Fang, Y. Bao, K. **ang, W. Jia in Diabetologia (2009)

Article

Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population

Recent genome-wide association studies in East Asian populations reported that single nucleotide polymorphisms (SNPs) in KCNQ1 are associated with type 2 diabetes. The aim of this study was to validate this findi...

C. Hu, C. Wang, R. Zhang, X. Ma, J. Wang, J. Lu, W. Qin, Y. Bao, K. **ang… in Diabetologia (2009)

Article

Association of genetic variants of NOS1AP with type 2 diabetes in a Chinese population

Chromosome 1q21-q24 has been shown to be linked to type 2 diabetes. The International Type 2 Diabetes 1q Consortium showed that one of the nominal associations was located in the NOS1AP gene. Although this associ...

C. Hu, C. Wang, R. Zhang, M. C. Ng, Y. Bao, C. Wang, W. Y. So, R. C. Ma… in Diabetologia (2010)

Article

Contribution of visceral fat accumulation to carotid intima–media thickness in a Chinese population

Recent observational studies have reported that body fat distribution might be differentially associated with subclinical atherosclerosis. We previously reported that visceral fat area (VFA) ⩾80 cm² is the optima...

Y Wang, X Ma, M Zhou, W Zong, L Zhang, Y Hao, J Zhu… in International Journal of Obesity (2012)

Article

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes

Human complex metabolic traits are in part regulated by genetic determinants. Here we applied exome sequencing to identify novel associations of coding polymorphisms at minor allele frequencies (MAFs) >1% with...

A. Albrechtsen, N. Grarup, Y. Li, T. Sparsø, G. Tian, H. Cao, T. Jiang… in Diabetologia (2013)

Article

Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4

Most genetic variants identified for type 2 diabetes have been discovered in European populations. We performed genome-wide association studies (GWAS) in a Chinese population with the aim of identifying novel ...

R. C. W. Ma, C. Hu, C. H. Tam, R. Zhang, P. Kwan, T. F. Leung, G. N. Thomas… in Diabetologia (2013)

Article

Ghrelin receptor regulates HFCS-induced adipose inflammation and insulin resistance

High fructose corn syrup (HFCS) is the most commonly used sweetener in the United States. Some studies show that HFCS consumption correlates with obesity and insulin resistance, while other studies are in disa...

X Ma, L Lin, J Yue, G Pradhan, G Qin, L J Minze, H Wu… in Nutrition & Diabetes (2013)

Article

Analysis of variants and mutations in the human winged helix FOXA3 gene and associations with metabolic traits

The forkhead factor Foxa3 is involved in the early transcriptional events controlling adipocyte differentiation and plays a critical function in fat depot expansion in response to high-fat diet regimens and du...

D C Adler-Wailes, A T Alberobello, X Ma, L Hugendubler… in International Journal of Obesity (2015)

Article

Short-term weight-centric effects of tea or tea extract in patients with metabolic syndrome: a meta-analysis of randomized controlled trials

To evaluate the weight-centric effect of tea or tea extract in participants with metabolic syndrome (MetS), we performed electronic searches in PubMed, EmBase and the Cochrane Library to identify eligible rand...

X Zhong, T Zhang, Y Liu, X Wei, X Zhang, Y Qin, Z **, Q Chen, X Ma… in Nutrition & Diabetes (2015)

Article

Contribution of a first-degree family history of diabetes to increased serum adipocyte fatty acid binding protein levels independent of body fat content and distribution

First-degree relatives of patients with diabetes bear an increased risk of diabetes, overweight/obesity and cardiovascular disease. Accumulating evidence indicates that circulating concentrations of adipokines...

X Hu, X Pan, X Ma, Y Luo, Y Xu, Q **ong, Y **ao, Y Bao… in International Journal of Obesity (2016)

Article

The effect of glucose-dependent insulinotropic polypeptide (GIP) variants on visceral fat accumulation in Han Chinese populations

We aim to validate the effects of glucose-dependent insulinotropic polypeptide (GIP) on fat distribution and glucose metabolism in Han Chinese populations.

T Wang, X Ma, T Tang, K Higuchi, D Peng, R Zhang, M Chen, J Yan… in Nutrition & Diabetes (2017)