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Open AccessThe effect of glucose-dependent insulinotropic polypeptide (GIP) variants on visceral fat accumulation in Han Chinese populations
We aim to validate the effects of glucose-dependent insulinotropic polypeptide (GIP) on fat distribution and glucose metabolism in Han Chinese populations.
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Open AccessContribution of a first-degree family history of diabetes to increased serum adipocyte fatty acid binding protein levels independent of body fat content and distribution
First-degree relatives of patients with diabetes bear an increased risk of diabetes, overweight/obesity and cardiovascular disease. Accumulating evidence indicates that circulating concentrations of adipokines...
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Article
Open AccessAnalysis of variants and mutations in the human winged helix FOXA3 gene and associations with metabolic traits
The forkhead factor Foxa3 is involved in the early transcriptional events controlling adipocyte differentiation and plays a critical function in fat depot expansion in response to high-fat diet regimens and du...
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Open AccessShort-term weight-centric effects of tea or tea extract in patients with metabolic syndrome: a meta-analysis of randomized controlled trials
To evaluate the weight-centric effect of tea or tea extract in participants with metabolic syndrome (MetS), we performed electronic searches in PubMed, EmBase and the Cochrane Library to identify eligible rand...
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Article
Open AccessGhrelin receptor regulates HFCS-induced adipose inflammation and insulin resistance
High fructose corn syrup (HFCS) is the most commonly used sweetener in the United States. Some studies show that HFCS consumption correlates with obesity and insulin resistance, while other studies are in disa...
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Open AccessGenome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4
Most genetic variants identified for type 2 diabetes have been discovered in European populations. We performed genome-wide association studies (GWAS) in a Chinese population with the aim of identifying novel ...
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Open AccessExome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
Human complex metabolic traits are in part regulated by genetic determinants. Here we applied exome sequencing to identify novel associations of coding polymorphisms at minor allele frequencies (MAFs) >1% with...
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Open AccessContribution of visceral fat accumulation to carotid intima–media thickness in a Chinese population
Recent observational studies have reported that body fat distribution might be differentially associated with subclinical atherosclerosis. We previously reported that visceral fat area (VFA) ⩾80 cm2 is the optima...
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Association of genetic variants of NOS1AP with type 2 diabetes in a Chinese population
Chromosome 1q21-q24 has been shown to be linked to type 2 diabetes. The International Type 2 Diabetes 1q Consortium showed that one of the nominal associations was located in the NOS1AP gene. Although this associ...
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Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population
Recent genome-wide association studies in East Asian populations reported that single nucleotide polymorphisms (SNPs) in KCNQ1 are associated with type 2 diabetes. The aim of this study was to validate this findi...
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A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population
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A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population
Single nucleotide polymorphisms (SNPs) in G6PC2 have been reported to be associated with fasting plasma glucose level in several populations of European descent. However, whether G6PC2 variants have a similar eff...