6 Result(s)
within
Wulf Tonnus
Biochemistry, general
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Article
Open AccessThe importance of murine phospho-MLKL-S345 in situ detection for necroptosis assessment in vivo
Necroptosis is a caspase-independent modality of cell death implicated in many inflammatory pathologies. The execution of this pathway requires the formation of a cytosolic platform that comprises RIPK1 and RI...
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Article
Open AccessGasdermin D-deficient mice are hypersensitive to acute kidney injury
Signaling pathways of regulated necrosis, such as necroptosis and ferroptosis, contribute to acute kidney injury (AKI), but the role of pyroptosis is unclear. Pyroptosis is mediated by the pore-forming protein...
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Article
Open AccessRubicon-deficiency sensitizes mice to mixed lineage kinase domain-like (MLKL)-mediated kidney ischemia-reperfusion injury
The cytosolic protein rubicon (RUBCN) has been implicated in the removal of necrotic debris and autoimmunity. However, the role of RUBCN in models of acute kidney injury (AKI), a condition that typically invol...
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Article
Open AccessCorrection to: Phenytoin inhibits necroptosis
The name of the one of the authors was misspelt. The author’s surname is Rodriguez, not Rodriquez as originally published. This has been corrected in both the PDF and HTML versions of the Article.
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Article
Open AccessPhenytoin inhibits necroptosis
Receptor-interacting protein kinases 1 and 3 (RIPK1/3) have best been described for their role in mediating a regulated form of necrosis, referred to as necroptosis. During this process, RIPK3 phosphorylates m...
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Article
Open AccessSorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury
Necroptosis contributes to the pathophysiology of several inflammatory, infectious and degenerative disorders. TNF-induced necroptosis involves activation of the receptor-interacting protein kinases 1 and 3 (R...
