36,427 Result(s)
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Open AccessHarnessing virus flexibility to selectively capture and profile rare circulating target cells for precise cancer subty**
The effective isolation of rare target cells, such as circulating tumor cells, from whole blood is still challenging due to the lack of a capturing surface with strong target-binding affinity and non-target-ce...
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Open AccessInterpretable machine learning for the prediction of death risk in patients with acute diquat poisoning
The aim of this study was to develop and validate predictive models for assessing the risk of death in patients with acute diquat (DQ) poisoning using innovative machine learning techniques. Additionally, pred...
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Open AccessAssociation of volatile organic compound levels with chronic obstructive pulmonary diseases in NHANES 2013–2016
Volatile organic compounds (VOCs) represent a significant component of air pollution. However, studies evaluating the impact of VOC exposure on chronic obstructive pulmonary disease (COPD) have predominantly f...
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Open AccessPlasmonic trimers designed as SERS-active chemical traps for subty** of lung tumors
Plasmonic materials can generate strong electromagnetic fields to boost the Raman scattering of surrounding molecules, known as surface-enhanced Raman scattering. However, these electromagnetic fields are hete...
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Open AccessEfficient molecular do** of polymeric semiconductors improved by coupled reaction
Exploring chemical do** method to improve the electrical conductivity of polymers is still very attractive for researchers. In this work, we report a developed method of do** a polymer semiconductor aided ...
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Open AccessDynamics of single-nuclei transcriptomic profiling of adipose tissue from diverse anatomical locations during mouse aging process
Adipose tissue plays critical roles in an individual’s aging process. In this research, we use single-nucleus RNA sequencing to create highly detailed transcriptional maps of subcutaneous adipose tissue and vi...
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Open AccessBi-directional context-aware network for the nested named entity recognition
The Span-based model can effectively capture the complex entity structure in the text, thus becoming the mainstream model for nested named entity recognition (Nested NER) tasks. However, traditional Span-based...
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Open AccessInhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer
Tumor cells reprogram their metabolism to produce specialized metabolites that both fuel their own growth and license tumor immune evasion. However, the relationships between these functions remain poorly unde...
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Open AccessPreoperative prediction of MGMT promoter methylation in glioblastoma based on multiregional and multi-sequence MRI radiomics analysis
O6-methylguanine-DNA methyltransferase (MGMT) has been demonstrated to be an important prognostic and predictive marker in glioblastoma (GBM). To establish a reliable radiomics model based on MRI data to predi...
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Open AccessNumerical simulation of blasting behavior of rock mass with cavity under high in-situ stress
With the shift of coal seam mining to the deep, the in-situ stress of coal and rock mass increases gradually. High ground stress can limit the generation of rock cracks caused by blasting, and blasting usually...
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Open AccessA scalable and cGMP-compatible autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa
We present Dystrophic Epidermolysis Bullosa Cell Therapy (DEBCT), a scalable platform producing autologous organotypic iPS cell-derived induced skin composite (iSC) grafts for definitive treatment. Clinical-gr...
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Open AccessThe selection of a surgical strategy for the treatment of adult degenerative scoliosis with "pear-shaped" decompression under open spinal endoscopy
The prognoses of patients who undergo open spinal endoscopy (OSE) decompression significantly differ by scoliosis type and symptom despite the use of uniform standards and procedures for the decompression surg...
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Open AccessTurnover intention and its related factors of clinical research coordinator in Hunan, China: a cross-sectional study
To explore the related factors of turnover intention in clinical research coordinators (CRCs) and assess the mediating effects of professional identity on the association between job burnout and turnover inten...
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Open AccessMorphological classification of neurons based on Sugeno fuzzy integration and multi-classifier fusion
In order to extract more important morphological features of neuron images and achieve accurate classification of the neuron type, a method is proposed that uses Sugeno fuzzy integral integration of three opti...
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Open AccessWhite-light activatable organic NIR-II luminescence nanomaterials for imaging-guided surgery
While second near-infrared (NIR-II) fluorescence imaging is a promising tool for real-time surveillance of surgical operations, the previously reported organic NIR-II luminescent materials for in vivo imaging ...
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Open AccessThe protective effect of ginsenoside Rg1 against sepsis-induced lung injury through PI3K-Akt pathway: insights from molecular dynamics simulation and experimental validation
Sepsis-induced acute lung injury (SALI) poses a significant threat with high incidence and mortality rates. Ginsenoside Rg1 (GRg1), derived from Ginseng in traditional Chinese medicine, has been found to reduc...
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Open AccessExploring usage pattern variation of free-floating bike-sharing from a night travel perspective
Free-floating bike sharing (FFBS) attracts increasing research focusing on usage patterns, determining factors, and integrated transportation. However, existing researchers tend to overlook the variation in us...
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Open AccessNatural variation of TBR confers plant zinc toxicity tolerance through root cell wall pectin methylesterification
Zinc (Zn) is an essential micronutrient but can be cytotoxic when present in excess. Plants have evolved mechanisms to tolerate Zn toxicity. To identify genetic loci responsible for natural variation of plant ...
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Open AccessSite-specific apparent optimum air temperature for vegetation photosynthesis across the globe
The apparent optimum air temperature for vegetation photosynthesis (Topt) is a key temperature parameter in terrestrial ecosystem models estimating daily photosynthesis or gross primary production (GPP, g C/m2/da...
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Open AccessUrban greenspace types and climate factors jointly drive the microbial community structure and co-occurrence network
The benefits of urban green space are socially widely recognized as a direct link between plant–microbe interactions and the maintenance of biodiversity, community stability, and ecosystem functioning. Neverth...
