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Article
Cytotoxic constituents from the roots ofAnthriscus sylvestris
Activity-guided fractionation of the roots ofAnthriscus sylvestris resulted in the isolation and characterization of five cytotoxic compounds, deoxypodophyllotoxin (1), falcarindiol (2), and angeloyl podophylloto...
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Article
Analgesic and hypothermic activities of melandrin
Melandrin exhibited an analgesic activity as assessed by inhibition of writhing syndrome in mice and by pressure method of inflamed paws of rats and inflamed tails of mice, and showed a hypothermic effect. How...
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Article
Dentatins: Sesquiterpene glucosides fromIxeris dentata
Three new sesquiterpene lactone glucosides named dentatins A, B and C were isolated fromIxeris dentata and the structures were elucidated as 3β, 8β-dihydroxy-(1α, 5α)-guaian-10(14)-ene-6α, 12-olide-3-O-β-D-glucop...
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Article
Antiinflammatory principle ofBupleurum longiradiatum roots
A methanol extract of the roots ofBupleurum longiradiatum (Umbelliferae) showed antiinflammatory activity in rats. Hexane, chloroform, butanol, and aqueous fractions from the methanol extract were tested with the...
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Article
Effects of naturally occurring furanocoumarins on lipid peroxidation and carbon tetrachloride induced hepatotoxicity in mice
Several naturally occurring furanocoumarins significantly inhibited microsomal lipid peroxidation not only mediated by endogeneous iron and NADPH but also initiated by CCl4 metabolites. Phellopterin, a potent inh...
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Article
Flavonoids from the rhizomes ofBelamcanda chinensis
Two flavonoids were isolated from the rhizomes ofBelamcanda chinensis and identified as kanzakiflavove-2 and 2R: 3R-dihydrokaempferol-7-methylether, respectively.
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Article
The chiroptical properties and absolute configuration of 28-nor-β-amyrins
The existence in nature of two isomers of 28-nortriterpenes is known. One is normal D/Ecis form and the other is 17α-hydrogen D/Etrans form. Since the latter cannot exist with ring D in the chair conformation, th...
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Article
Two minor furanocoumarins ofAngelica dahurica
Two minor constituents were isolated from the roots ofAngelica dahurica and identified as isooxypeucedanin and gosferol, respectively.
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Article
Phytochemical study onPrunus davidiana
From the stem ofPrunus davidiana, naringenin and its glucoside, kaempferol and its glucoside, dihydrokaempferol, kaempferide glucoside, hesperetin glucoside, quercetin glucoside, d-catechin and β-sitosterol gluco...
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Article
Effects of lignans on hepatic drug-metabolizing enzymes
The effects of lignans, related to macelignan, on hepatic microsomal drug-metabolizing enzyme (DME) activity were evaluated to elucidate the structure-activity relationship in mice and rats. The compounds carr...
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Article
Flavonoid glycosides fromMelandrium firmum
Linarin and schaftoside were isolated fromMelandrium firmum (Caryophyllaceae) and characterized by spectral data.
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Article
Isolation of hepatic drug metabolism inhibitors from the Rhizomes ofCurcuma zedoaria
The methanolic extract of the Rhizome ofCurcuma zedoaria exhibited a significant prolongation of hexobarbital (HB)-induced hypnosis. Through liquid chromatography of an ether soluble fraction, monitoring by bioas...
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Article
Phenolic compounds of the roots ofBupleurum longeradiatum
Emodin-8-O-β-D-glucoside and narcissin were isolated from the roots ofBupleurum longeradiatum.
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Article
Isolation of a β-carboline alkaloid from the leaves ofAllium tuberosum
(−)-(3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid and L-tyrosine were isolated from the leaves ofAllium tuberosum and characterized by spectral analysis. The isolation of the former compound from the natu...
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Article
Isolation of hepatic drug metabolism inhibitors from the seeds ofMyristica fragrans
The hexane extract from Nutmeg, the seed ofMyristica fragrans significantly inhibited hepatic drug-metabolizing enzyme activity. Through systematic fractionation by SiO2 column and vacuum liquid chromatography mo...
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Article
Effects of psoralen and angelicin on hepatic drug-metabolizing enzyme activities
The effects of psoralen and angelicin on hepatic microsomal drug-metabolizing enzyme (DME) activities were investigated to elucidate the mode of the interaction of furanocoumarins with DME system. A single adm...
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Article
Further study on the constituents ofRhododendron brachycarpum
From the leaves ofRhododendron brachycarpum, rhododendrin, grayanotoxin I and guaijaverin were isolated and characterized by spectral data.
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Article
Flavonoids from the leaves ofRhododendron brachycarpum
The flavonoids isolated from the leaves ofRhododendron brachycarpum, were identified as quercetin, avicularin, quercitrin and hyperin.
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Article
Synthesis of epialeuritolic acid
The triterpenoid isolated from the seeds of Phytolacca plants was confirmed to be acetylaleuritolic acid rather than acetylepialeuritolic acid by direct comparison with synthetic compounds.
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Article
Inhibition of hepatic microsomal drug-metabolizing enzymes by imperatorin
The effect of imperatorin on hepatic microsomal mixed function oxidases (MFO) was investigated. On acute treatment, imperatorin (30 mg/kg, i.p.) caused a significant reduction in activities of hepatic aminopyr...
