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Human pharmacogenomics: The development of a science
Until about 50 years ago, the altering of a normal drug effect by a genetic deficiency was only rarely observed. Here, my discovery of the genetic variant of butyrylcholinesterase affecting succinylcholine act...
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Atypical plasma cholinesterase. A personal discovery story: a tale of three cities
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Comparison of effects of several inhalation anaesthetics on caffeine-induced contractures of normal and malignant hyperthermic skeletal muscle
We have compared the combined effects of halothane, enflurane, isoflurane and methoxyflurane on caffeine-induced contractures of normal and malignant hyperthermia susceptible (MHS) skeletal muscle fascicles. W...
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The adenosine triphosphate (ATP) depletion test: Comparison with the caffeine contracture test as a method of diagnosing malignant hyperthermia susceptibility
The adenosine triphosphate (ATP depletion ratio, which is the ratio [ATP] in skeletal muscle equilibrated with carbogen and 4% halothane for 30 minutes/
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Errata
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Malignant hyperthermia: an investigation of five patients
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A clinical and laboratory evaluation of four fluothane vaporizers
A la suite de ľintérêt qu’on a porté, récemment, au Fluothane, on a dû fabriquer plusieurs vaporisateurs pour administrer cet agent anesthésique puissant. Cet article fait part des résultats des recherches de ...
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Spectrophotometric determination of fluothane vapour
The optical properties of Fluothane vapour have been determined. There was a strong absorption of ultraviolet and infrared radiation. While the absorption in either range can be used to measure the concentrati...
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The relation of plasma cholinesterases to response to clinical doses of succinylcholine
The plasma cholinesterase of a normal adult is capable of destroyingin vitro up to 120 mg. per minute of succinylcholme chloride. This great speed of destruction cannot be obtainedin vivo, yet the normal plasma c...
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Experiments with animals on the combined action of procaine and barbiturates
Procaine prolonged the sleep of guinea-pigs induced by pentobarbital.