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Article
Open AccessStrain level microbial detection and quantification with applications to single cell metagenomics
Computational identification and quantification of distinct microbes from high throughput sequencing data is crucial for our understanding of human health. Existing methods either use accurate but computationa...
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Article
Open AccessHarnessing synthetic lethality to predict the response to cancer treatment
While synthetic lethality (SL) holds promise in develo** effective cancer therapies, SL candidates found via experimental screens often have limited translational value. Here we present a data-driven approac...
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Article
Open AccessPutative functional genes in idiopathic dilated cardiomyopathy
Idiopathic dilated cardiomyopathy (DCM) is a complex disorder with a genetic and an environmental component involving multiple genes, many of which are yet to be discovered. We integrate genetic, epigenetic, t...