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    Sirt1 deficiency upregulates glutathione metabolism to prevent hepatocellular carcinoma initiation in mice

    Sirtuin-1 (SIRT1) is involved in various metabolic pathways, including fatty acid synthesis and gluconeogenesis in the liver. However, its role in initiation and progression of liver cancer remains unclear. St...

    Pengxiang Qiu, Weilong Hou, Haitao Wang, Kimmy Ka Wing Lei, Shaowei Wang… in Oncogene (2021)