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Article
Single-cell patterning and axis characterization in the murine and human definitive endoderm
Defining the precise regionalization of specified definitive endoderm progenitors is critical for understanding the mechanisms underlying the generation and regeneration of respiratory and digestive organs, ye...
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Article
Sequential progenitor states mark the generation of pancreatic endocrine lineages in mice and humans
The pancreatic islet contains multiple hormone+ endocrine lineages (α, β, δ, PP and ε cells), but the developmental processes that underlie endocrinogenesis are poorly understood. Here, we generated novel mouse l...
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Chapter
Genetic Regulatory Networks Guiding Islet Development
The pancreatic islet is a mini-organ that consists of several hormone-secreting endocrine cell types in adults. Islets execute a vital physiological function in regulating glucose homeostasis, and endocrine ce...