4 Result(s)
within
Wei-Jia Wang
English
Cell Biology
Life Sciences, general
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Article
Open AccessMannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P
Pyroptosis is a type of regulated cell death executed by gasdermin family members. However, how gasdermin-mediated pyroptosis is negatively regulated remains unclear. Here, we demonstrate that mannose, a hexos...
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Article
Open AccessRab31 promotes metastasis and cisplatin resistance in stomach adenocarcinoma through Twist1-mediated EMT
Stomach adenocarcinoma (STAD) is one of the leading causes of cancer-related death globally. Metastasis and drug resistance are two major causes of failures in current chemotherapy. Here, we found that the exp...
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Article
Open AccessThe metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8
Pyroptosis is a form of regulated cell death mediated by gasdermin family members, among which the function of GSDMC has not been clearly described. Herein, we demonstrate that the metabolite α-ketoglutarate (...
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Article
Open AccessArgonaute 2 is a key regulator of maternal mRNA degradation in mouse early embryos
In mammalian early embryos, the transition from maternal to embryonic control of gene expression requires timely degradation of a subset of maternal mRNAs (MRD). Recently, zygotic genome activation (ZGA)-depen...
