41 Result(s)
within
Wei-**ng Bao
Biomedicine, general
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Article
Dynamic shielding of bacterial outer membrane vesicles for safe and efficient chemo-immunotherapy against tumors
Bacterial outer membrane vesicles (OMVs) are potent immunostimulants of regulating the tumor microenvironment (TME) for immunotherapy, and can be used to deliver drugs. However, the severe systemic inflammator...
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Article
Role of magnetic resonance imaging features in diagnosing and localization of disc rupture related to cervical spinal cord injury without radiographic abnormalities
A retrospective study.
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Article
Open AccessCompensatory remodeling of a septo-hippocampal GABAergic network in the triple transgenic Alzheimer’s mouse model
Alzheimer’s disease (AD) is characterized by a progressive loss of memory that cannot be efficiently managed by currently available AD therapeutics. So far, most treatments for AD that have the potential to im...
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Article
Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin
Fibrosis is caused by extensive deposition of extracellular matrix (ECM) components, which play a crucial role in injury repair. Fibrosis attributes to ~45% of all deaths worldwide. The molecular pathology of ...
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Article
Open AccessCalcitriol increases MBNL1 expression and alleviates myotonic dystrophy phenotypes in HSALR mouse models
Myotonic dystrophy type 1 (DM1), one of the most common forms of adult-onset muscular dystrophy, is caused by abnormally expanded CTG repeats in the 3′ untranslated region of the DMPK gene. The CUG repeats transc...
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Article
Open AccessLRIG2 regulates cell proliferation, migration and apoptosis of osteosarcoma
Osteosarcoma (OS) is one of the malignant bone tumors with strong aggressiveness and poor prognosis. Leucine-rich repeats and immunoglobulin-like domains2 (LRIG2) is closely associated with the poor prognosis ...
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Article
Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation
Liver fibrosis is one of the most severe pathologic consequences of chronic liver diseases, and effective therapeutic strategies are urgently needed. Proton pump inhibitors (PPIs) are H+/K+-ATPase inhibitors and ...
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Open AccessCharacterization of genomic alterations in Chinese colorectal cancer patients with liver metastases
The exploration of genomic alterations in Chinese colorectal liver metastasis (CRLM) is limited, and corresponding genetic biomarkers for patient’s perioperative management are still lacking. This study aims t...
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Article
Open AccessACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques
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Article
Cloning and characterization of an oxiranedicarboxylate hydrolase from Labrys sp. WH-1
This study aimed to clone and characterize the oxiranedicarboxylate hydrolase (ORCH) from Labrys sp. WH-1.
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Article
Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer
We have reported that hepatitis B X-interacting protein (HBXIP, also termed LAMTOR5) can act as an oncogenic transcriptional co-activator to modulate gene expression, promoting breast cancer development. Pyruv...
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Article
Metabolic perturbations of post-load hyperglycemia vs. fasting hyperglycemia
There is evidence that post-load/post-meal hyperglycemia is a stronger risk factor for cardiovascular disease than fasting hyperglycemia. The underlying mechanism remains to be elucidated. The current study ai...
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Article
Association of serum uric acid levels with osteoporosis and bone turnover markers in a Chinese population
Recent evidence shows that uric acid is protective against some neurological diseases, but can be detrimental in many metabolic and cardiovascular disorders. In this study, we examined the association between ...
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Article
Dual roles of QOA-8a in antiosteoporosis: a combination of bone anabolic and anti-resorptive effects
Osteoporotic treatments have largely depended on antiresorptive or anabolic drugs; but the former also suppresses new bone formation, and the latter only includes human parathyroid hormone. There is no drug th...
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Article
Association of bone turnover markers with glucose metabolism in Chinese population
The association between type 2 diabetes (T2DM) and bone metabolism has been discussed previously but is controversial. In this study we aimed to evaluate the association of bone turnover markers with glucose m...
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Article
Polymorphisms of the KCNQ1 gene are associated with the therapeutic responses of sulfonylureas in Chinese patients with type 2 diabetes
KCNQ1 channel is a member of the voltage-gated potassium channel KQT-like subfamily. The KCNQ1 gene has recently been identified as a susceptibility locus for type 2 diabetes mellitus (T2DM). In the present study...
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Open AccessCancer incidence in urban Shanghai, 1973-2010: an updated trend and age-period-cohort effects
To provide a comprehensive overview of temporal trends in cancer incidence during 1973–2010 in urban Shanghai.
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Inverse relationship between serum osteocalcin levels and nonalcoholic fatty liver disease in postmenopausal Chinese women with normal blood glucose levels
Osteocalcin is involved in the progression of nonalcoholic fatty liver disease (NAFLD) in animal models and humans. In this study we investigated the relationship between serum osteocalcin levels and NAFLD in ...
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Open AccessAnti-tumor enhancement of Fei-Liu-** ointment in combination with celecoxib via cyclooxygenase-2-mediated lung metastatic inflammatory microenvironment in Lewis lung carcinoma xenograft mouse model
Fei-Liu-** (FLP) ointment is an oral prescription medication that has been widely applied to treat lung cancer patients in China. Regulation of the metastatic microenvironment is an important therapeutic app...
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Article
Establishment and maintenance of a standardized glioma tissue bank: Huashan experience
Cerebral glioma is the most common brain tumor as well as one of the top ten malignant tumors in human beings. In spite of the great progress on chemotherapy and radiotherapy as well as the surgery strategies ...
