![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Open AccessA chromosomal-scale genome assembly of modern cultivated hybrid sugarcane provides insights into origination and evolution
Sugarcane is a vital crop with significant economic and industrial value. However, the cultivated sugarcane’s ultra-complex genome still needs to be resolved due to its high ploidy and extensive recombination ...
-
Article
Open AccessHomolytic H2 dissociation for enhanced hydrogenation catalysis on oxides
The limited surface coverage and activity of active hydrides on oxide surfaces pose challenges for efficient hydrogenation reactions. Herein, we quantitatively distinguish the long-puzzling homolytic dissociat...
-
Article
Open AccessExperimental study on failure characteristics and rheological properties of pillar-like rock samples with different shapes
The stability of coal pillar is extremely important to the control of rock strata movement and surface subsidence. It is of great significance for mining design to analyze the stability and failure characteris...
-
Article
Open AccessEpidemiological characteristics and temporal-spatial clustering analysis on human brucellosis in Jiangsu Province, 2006–2021
The marked increase in the incidence rate of brucellosis is a serious public health concern in Jiangsu Province. However, its temporal and spatial distribution has not been studied in depth. The main purpose o...
-
Article
Open AccessIdentification of PCB congeners and their thresholds associated with diabetes using decision tree analysis
Few studies have investigated the potential combined effects of multiple PCB congeners on diabetes. To address this gap, we used data from 1244 adults in the National Health and Nutrition Examination Survey (N...
-
Article
Open AccessGenome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study o...
-
Article
Open AccessParabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice
Parabacteroides distasonis (P. distasonis) plays an important role in human health, including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that P. distasonis is decreased in patients ...
-
Article
Open AccessWhole genome sequence analysis of blood lipid levels in >66,000 individuals
Blood lipids are heritable modifiable causal factors for coronary artery disease. Despite well-described monogenic and polygenic bases of dyslipidemia, limitations remain in discovery of lipid-associated allel...
-
Article
Open AccessRecent climate change has driven divergent hydrological shifts in high-latitude peatlands
High-latitude peatlands are changing rapidly in response to climate change, including permafrost thaw. Here, we reconstruct hydrological conditions since the seventeenth century using testate amoeba data from ...
-
Article
Open AccessGenomic signatures define three subtypes of EGFR-mutant stage II–III non-small-cell lung cancer with distinct adjuvant therapy outcomes
The ADJUVANT study reported the comparative superiority of adjuvant gefitinib over chemotherapy in disease-free survival of resected EGFR-mutant stage II–IIIA non-small cell lung cancer (NSCLC). However, not all ...
-
Article
Open AccessDiagnosis of extracranial carotid stenosis by MRA of the brain
Severe extracranial carotid stenosis (SECS) patients may present with nonspecific neurological symptoms that require intracranial magnetic resonance imaging (MRI) and time-of-flight (TOF)-MR angiography (MRA) ...
-
Article
Open AccessChronic liver disease not a significant comorbid condition for COVID-19
To explore the role of chronic liver disease (CLD) in COVID-19. A total of 1439 consecutively hospitalized patients with COVID-19 from one large medical center in the United States from March 16, 2020 to April...
-
Article
Open AccessA rapid screening model for early predicting novel coronavirus pneumonia in Zhejiang Province of China: a multicenter study
Novel coronavirus pneumonia (NCP) has been widely spread in China and several other countries. Early finding of this pneumonia from huge numbers of suspects gives clinicians a big challenge. The aim of the stu...
-
Article
Open AccessLasting antibody and T cell responses to SARS-CoV-2 in COVID-19 patients three months after infection
The dynamics, duration, and nature of immunity produced during SARS-CoV-2 infection are still unclear. Here, we longitudinally measured virus-neutralising antibody, specific antibodies against the spike (S) pr...
-
Article
Open AccessIn silico analysis of epitope-based vaccine candidate against tuberculosis using reverse vaccinology
Tuberculosis (TB) kills more individuals in the world than any other disease, and a threat made direr by the coverage of drug-resistant strains of Mycobacterium tuberculosis (Mtb). Bacillus Calmette–Guérin (BCG) ...
-
Article
Open AccessRetrospective study of preoperative chemoradiotherapy with capecitabine versus capecitabine plus oxaliplatin for locally advanced rectal cancer
This study aimed to evaluate whether the addition of oxaliplatin to a neoadjuvant chemoradiotherapy (CRT) regimen could improve survival benefit in locally advanced rectal cancer (LARC) patients. We retrospect...
-
Article
Open AccessAllele-aware chromosome-level genome assembly and efficient transgene-free genome editing for the autotetraploid cultivated alfalfa
Artificially improving traits of cultivated alfalfa (Medicago sativa L.), one of the most important forage crops, is challenging due to the lack of a reference genome and an efficient genome editing protocol, whi...
-
Article
Entanglement of two quantum memories via fibres over dozens of kilometres
A quantum internet that connects remote quantum processors1,2 should enable a number of revolutionary applications such as distributed quantum computing. Its realization will rely on entanglement of remote quantu...
-
Article
Open AccessTemporal Differentiation of Crop Growth as One of the Drivers of Intercrop** Yield Advantage
Intercrop** studies usually focus on yield advantage and interspecific interactions but few quantify temporal niche differentiation and its relationship with intercrop** yield advantage. A field experiment...
-
Article
Open AccessPublisher Correction: Utf1 contributes to intergenerational epigenetic inheritance of pluripotency
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.