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  1. No Access

    Article

    Production of rosmarinic acid in high density perfusion cultures ofAnchusa officinalis using a high sugar medium

    The most direct approach to enhancing the volumetric yield of secondary metabolites in plant tissue cultures is to operate the culture under high cell density. In this study, a cell suspension ofAnchusa officinal...

    Wei-Wen Su, Arthur E. Humphrey in Biotechnology Letters (1990)

  2. No Access

    Article

    Production of rosmarinic acid from perfusion culture ofAnchusa officinalis in a membrane-aerated bioreactor

    In this study, a perfusion fermentation ofAnchusa officinalis was carried out in a stirred tank bioreactor integrated with an internal cross-flow filter. Bubble-free aeration via microporous membrane fibers was u...

    Wei Wen Su, Arthur E. Humphrey in Biotechnology Letters (1991)

  3. No Access

    Article

    Rosmarinic acid production in perfused Anchusa officinalis culture: Effect of inoculum size

    High cell density and rosmarinic acid (RA) productivity have been achieved by applying periodic culture perfusion to the Anchusa officinalis cell suspension. In this study, the effect of inoculum size on cell gro...

    Wei Wen Su, Fei Lei in Biotechnology Letters (1993)

  4. No Access

    Article

    Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays

    Chromosomal imbalances such as deletions and amplifications are common rearrangements in most tumors1. Specific rearrangements are consistently associated with specific tumor types or stages, implicating the role...

    Wei-Wen Cai, Jian-Hua Mao, Chi-Wen Chow, Shamsha Damani… in Nature Biotechnology (2002)

  5. No Access

    Protocol

    Detection of DNA Copy Number Alterations in Complex Genomes Using Array Comparative Genomic Hybridization

    Array-based comparative genomic hybridization (array CGH) is becoming a prominent genomic technology with many important applications in biomedical research. Although several platforms of this technology have ...

    Wei-Wen Cai in Microarrays (2007)

  6. No Access

    Article

    Population structure and association map** on chromosome 7 using a diverse panel of Chinese germplasm of rice (Oryza sativa L.)

    The majority of 170 rice accessions used in this study were diverse landraces or varieties from a putative mini-core collection of Chinese germplasm along with some widely used parental lines in genetic analys...

    Weiwei Wen, Hanwei Mei, Fangjun Feng, Sibin Yu… in Theoretical and Applied Genetics (2009)

  7. No Access

    Article

    The strategy and potential utilization of temperate germplasm for tropical germplasm improvement: a case study of maize (Zea mays L.)

    The organization of maize (Zea mays L.) germplasm into genetically divergent heterotic groups is the foundation of a successful hybrid maize breeding program. In this study, 94 CIMMYT maize lines (CMLs) and 54 Un...

    Weiwei Wen, Tingting Guo, Victor H. Chavez Tovar, Huihui Li… in Molecular Breeding (2012)

  8. No Access

    Article

    Enhancement of vindoline and vinblastine production in suspension-cultured cells of Catharanthus roseus by artemisinic acid elicitation

    Elicitation is an important strategy to improve production of secondary metabolites in vitro. Artemisinic acid was studied as a novel elicitor to enhance the yield of terpenoid indole alkaloids in the present ...

    **wei Liu, Jianhua Zhu, Le Tang, Wei Wen… in World Journal of Microbiology and Biotechn… (2014)

  9. No Access

    Article

    Map** quantitative trait loci for peroxidase activity and develo** gene-specific markers for TaPod-A1 on wheat chromosome 3AL

    Three novel QTL for peroxidase activity were mapped, and gene-specific markers for TaPod-A1 were developed and validated using RILs derived from the Doumai/Shi 4185 cross and ...

    **gxin Wei, Hongwei Geng, Yan Zhang, **dong Liu… in Theoretical and Applied Genetics (2015)

  10. No Access

    Article

    TaTGW6-A1, an ortholog of rice TGW6, is associated with grain weight and yield in bread wheat

    The TGW6 gene encodes a novel indole-3-acetic acid-glucose hydrolase and plays a significant role in improving thousand grain weight (TGW) and yield in rice. In the current study, a TGW6 ortholog from bread wheat...

    Mamoona Hanif, Fengmei Gao, **dong Liu, Weie Wen, Yingjun Zhang… in Molecular Breeding (2015)

  11. No Access

    Article

    Genome-wide linkage map** of flour color-related traits and polyphenol oxidase activity in common wheat

    Fifty-six QTL for flour color-related traits and polyphenol oxidase activity were identified using a genome-wide linkage map** of data from a RIL population derived from a Gaocheng 8901/Zhoum...

    Shengnan Zhai, Zhonghu He, Weie Wen, Hui **… in Theoretical and Applied Genetics (2016)

  12. No Access

    Article

    Cloning of TaSST genes associated with water soluble carbohydrate content in bread wheat stems and development of a functional marker

    We cloned TaSST genes, developed a gene-specific marker for TaSST - D1 , and identifi...

    Yan Dong, Yan Zhang, Yonggui **ao, Jun Yan, **dong Liu… in Theoretical and Applied Genetics (2016)

  13. No Access

    Article

    Development and validation of KASP assays for genes underpinning key economic traits in bread wheat

    We developed and validated a robust marker toolkit for high-throughput and cost-effective screening of a large number of functional genes in wheat.

    Awais Rasheed, Weie Wen, Fengmei Gao, Shengnan Zhai… in Theoretical and Applied Genetics (2016)

  14. No Access

    Article

    Genome-wide linkage map** of QTL for black point reaction in bread wheat (Triticum aestivum L.)

    Nine QTL for black point resistance in wheat were identified using a RIL population derived from a Linmai 2/Zhong 892 cross and 90K SNP assay.

    **dong Liu, Zhonghu He, Ling Wu, Bin Bai, Weie Wen… in Theoretical and Applied Genetics (2016)

  15. No Access

    Article

    TaELF3-1DL, a homolog of ELF3, is associated with heading date in bread wheat

    Early flowering 3 (ELF3) is a regulator to modulate photoperiod flowering in Arabidopsis. The homologs of ELF3 in rice and barley also have been identified essential for regulation of flowering time. In the curre...

    **** Wang, Weie Wen, Mamoona Hanif, **anchun **a, Honggang Wang… in Molecular Breeding (2016)

  16. No Access

    Article

    Cloning of TaTPP-6AL1 associated with grain weight in bread wheat and development of functional marker

    Trehalose 6-phosphate phosphatase (TPP) dephosphorylates trehalose 6-phosphate to trehalose, an important growth regulator, and is involved in starch accumulation and grain yield. In this study, wheat TPP homolog...

    Pengfei Zhang, Zhonghu He, **uling Tian, Fengmei Gao, Dengan Xu… in Molecular Breeding (2017)

  17. No Access

    Article

    Intein-mediated assembly of tunable scaffoldins for facile synthesis of designer cellulosomes

    In this study, extended artificial scaffoldins possessing multiple cohesin modules were created in vivo by employing split-intein-mediated protein ligation. Artificial scaffoldins having one Clostridium thermocel...

    Zhenlin Han, Wei Wen Su in Applied Microbiology and Biotechnology (2018)

  18. No Access

    Article

    Genome-wide linkage map** of yield-related traits in three Chinese bread wheat populations using high-density SNP markers

    We identified 21 new and stable QTL, and 11 QTL clusters for yield-related traits in three bread wheat populations using the wheat 90 K SNP assay.

    Faji Li, Weie Wen, Zhonghu He, **dong Liu, Hui **… in Theoretical and Applied Genetics (2018)

  19. No Access

    Article

    Genome-wide variation patterns between landraces and cultivars uncover divergent selection during modern wheat breeding

    Genetic diversity, population structure, LD decay, and selective sweeps in 687 wheat accessions were analyzed, providing relevant guidelines to facilitate the use of the germplasm in wheat breeding.

    **dong Liu, Awais Rasheed, Zhonghu He, Muhammad Imtiaz… in Theoretical and Applied Genetics (2019)

  20. No Access

    Article

    Genetic dissection of a major QTL for kernel weight spanning the Rht-B1 locus in bread wheat

    Genetic dissection uncovered a major QTL QTKW.caas-4BS corresponding with a 483 kb deletion that included genes ZnF, EamA and Rht-B1. This deletion was associated with increased grain weight and semi-dwarf phenot...

    Dengan Xu, Weie Wen, Lu** Fu, Faji Li, Jihu Li… in Theoretical and Applied Genetics (2019)

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