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Article
Tannic Acid Impedes the Proliferation of Bladder Cancer Cells by Elevating Mitochondrial Pathways of Apoptosis
Bladder cancer stands as a prevailing neoplasm among men globally, distinguished for its pronounced malignancy attributed to invasiveness and metastatic proclivity. Tannic acid (TA), an organic compound in man...
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Article
Open AccessCircMAST1 inhibits cervical cancer progression by hindering the N4-acetylcytidine modification of YAP mRNA
Cervical cancer (CCa) is the fourth most common cancer among females, with high incidence and mortality rates. Circular RNAs (circRNAs) are key regulators of various biological processes in cancer. However, th...
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Article
Open AccessHIF-1α/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury
Endothelial cell (EC) injury accelerates the progression of diabetic macrovascular complications. Hypoxia is an important cause of EC injury. Hypoxia-inducible factor-1 alpha (HIF-1α) is an important hypoxia r...
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Article
Development and validation of high-throughput and low-cost STARP assays for genes underpinning economically important traits in wheat
We developed and validated 56 gene-specific semi-thermal asymmetric reverse PCR (STARP) markers for 46 genes of important wheat quality, biotic and abiotic stress resistance, grain yield, and adaptation-relate...
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Article
Genetic dissection of a major QTL for kernel weight spanning the Rht-B1 locus in bread wheat
Genetic dissection uncovered a major QTL QTKW.caas-4BS corresponding with a 483 kb deletion that included genes ZnF, EamA and Rht-B1. This deletion was associated with increased grain weight and semi-dwarf phenot...
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Article
Genome-wide variation patterns between landraces and cultivars uncover divergent selection during modern wheat breeding
Genetic diversity, population structure, LD decay, and selective sweeps in 687 wheat accessions were analyzed, providing relevant guidelines to facilitate the use of the germplasm in wheat breeding.
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Article
Genome-wide linkage map** of yield-related traits in three Chinese bread wheat populations using high-density SNP markers
We identified 21 new and stable QTL, and 11 QTL clusters for yield-related traits in three bread wheat populations using the wheat 90 K SNP assay.
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Article
Genome-wide linkage map** of QTL for black point reaction in bread wheat (Triticum aestivum L.)
Nine QTL for black point resistance in wheat were identified using a RIL population derived from a Linmai 2/Zhong 892 cross and 90K SNP assay.
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Article
Development and validation of KASP assays for genes underpinning key economic traits in bread wheat
We developed and validated a robust marker toolkit for high-throughput and cost-effective screening of a large number of functional genes in wheat.
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Article
Cloning of TaSST genes associated with water soluble carbohydrate content in bread wheat stems and development of a functional marker
We cloned TaSST genes, developed a gene-specific marker for TaSST - D1 , and identifi...
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Article
Genome-wide linkage map** of flour color-related traits and polyphenol oxidase activity in common wheat
Fifty-six QTL for flour color-related traits and polyphenol oxidase activity were identified using a genome-wide linkage map** of data from a RIL population derived from a Gaocheng 8901/Zhoum...
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Article
Map** quantitative trait loci for peroxidase activity and develo** gene-specific markers for TaPod-A1 on wheat chromosome 3AL
Three novel QTL for peroxidase activity were mapped, and gene-specific markers for TaPod-A1 were developed and validated using RILs derived from the Doumai/Shi 4185 cross and ...
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Article
Enhancement of vindoline and vinblastine production in suspension-cultured cells of Catharanthus roseus by artemisinic acid elicitation
Elicitation is an important strategy to improve production of secondary metabolites in vitro. Artemisinic acid was studied as a novel elicitor to enhance the yield of terpenoid indole alkaloids in the present ...
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Article
Population structure and association map** on chromosome 7 using a diverse panel of Chinese germplasm of rice (Oryza sativa L.)
The majority of 170 rice accessions used in this study were diverse landraces or varieties from a putative mini-core collection of Chinese germplasm along with some widely used parental lines in genetic analys...
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Detection of DNA Copy Number Alterations in Complex Genomes Using Array Comparative Genomic Hybridization
Array-based comparative genomic hybridization (array CGH) is becoming a prominent genomic technology with many important applications in biomedical research. Although several platforms of this technology have ...
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Article
Rosmarinic acid production in perfused Anchusa officinalis culture: Effect of inoculum size
High cell density and rosmarinic acid (RA) productivity have been achieved by applying periodic culture perfusion to the Anchusa officinalis cell suspension. In this study, the effect of inoculum size on cell gro...
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Article
Production of rosmarinic acid from perfusion culture ofAnchusa officinalis in a membrane-aerated bioreactor
In this study, a perfusion fermentation ofAnchusa officinalis was carried out in a stirred tank bioreactor integrated with an internal cross-flow filter. Bubble-free aeration via microporous membrane fibers was u...
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Article
Production of rosmarinic acid in high density perfusion cultures ofAnchusa officinalis using a high sugar medium
The most direct approach to enhancing the volumetric yield of secondary metabolites in plant tissue cultures is to operate the culture under high cell density. In this study, a cell suspension ofAnchusa officinal...