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Open AccessSensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice
Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but the underlying molecular mechanism remains unclear. We demonstrate here that acid-sensing ion channel 3 (ASIC3) exacerb...
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Article
Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2
Excessive acetaminophen (APAP) can induce neutrophil activation and hepatocyte death. Along with hepatocyte dysfunction and death, NETosis (a form of neutrophil-associated inflammation) plays a vital role in t...
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Article
A systematic review and meta-analysis of the efficacy of ketamine and esketamine on suicidal ideation in treatment-resistant depression
To systematically assess the evidence of efficacy and safety of the use of ketamine and esketamine for patients with treatment-resistant depression (TRD) with suicidal ideation (SI).
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Article
Measurement of Br(n,γ) cross sections up to stellar s-process temperatures at the CSNS Back-n
The neutron capture cross sections ( \({n,\gamma }\) n , ...
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Test of the colonization ability of the invasive alien plant Flaveria bidentis (Asteraceae) in southern China
The risk of invasion from exotic alien plants is enhanced by the increased global flow of humans and trade. Exploring the colonizing ability of invasive alien organisms in local areas is conducive to formulati...
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Article
Open AccessDevelopment and evaluation of short-form version of the Constitution in Chinese Medicine Questionnaire: study a new and best brief instrument of Chinese medicine for health management
More efficient instruments for body constitution identification are needed for clinical practice. We aimed to develop the short-form version of the Constitution in Chinese Medicine Questionnaire (CCMQ) and eva...
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Article
Associations of Blood and Cerebrospinal Fluid Aβ and tau Levels with Renal Function
Amyloid β (Aβ) and tau play pivotal roles in the pathogenesis of Alzheimer’s disease (AD). Previous studies have shown that brain-derived Aβ and tau can be cleared through transport into the periphery, and the...
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Article
Open AccessIndividual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential
Bats are reservoir hosts for many zoonotic viruses. Despite this, relatively little is known about the diversity and abundance of viruses within individual bats, and hence the frequency of virus co-infection a...
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Article
Physiological β-amyloid clearance by the liver and its therapeutic potential for Alzheimer’s disease
Cerebral amyloid-β (Aβ) accumulation due to impaired Aβ clearance is a pivotal event in the pathogenesis of Alzheimer’s disease (AD). Considerable brain-derived Aβ is cleared via transporting to the periphery....
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Article
Open Access20-Hydroxyecdysone counteracts insulin to promote programmed cell death by modifying phosphoglycerate kinase 1
The regulation of glycolysis and autophagy during feeding and metamorphosis in holometabolous insects is a complex process that is not yet fully understood. Insulin regulates glycolysis during the larval feedi...
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Article
Porous organic polymers: a progress report in China
Porous organic polymers (POPs) are porous materials composed of light elements such as C, H, N, and O. The benign characters, including large surface area, good physical and chemical stability, well-defined ch...
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Article
Open AccessA comparison between ultrasound-guided AIIS injection and radiography in the diagnosis of subspine im**ement in patients with FAI
Subspine im**ement (SSI) does not have effective diagnostic criteria, especially in patients who also have femoroacetabular im**ement (FAI). The classification of anterior inferior iliac spine (AIIS) morph...
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Article
The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic ...
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ASO Author Reflections: Comparison of Sarcopenia and Cachexia for Their Prognostic Value in Gastric Cancer Patients at Different TNM Stages After Gastrectomy
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Article
Construction of enantioenriched eight-membered lactones via Pd-catalyzed asymmetric (6+2) dipolar annulation
Concise synthesis of eight-membered lactones, a kind of medium-sized heterocycles widespread in many bioactive natural products, is highly significant. However, it still remains a challenge due to unfavorable ...
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Article
Shear behavior of bio-cemented calcareous sand treated through bio-stimulation under the direct shear condition
Microbially induced calcite precipitation (MICP) through the bio-stimulation approach is a promising ground improvement technique that can improve the engineering performance of calcareous sand. This study inv...
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Biochemical, Strength and Erosional Characteristics of Coral Sand Treated by Bio-Stimulated Microbial Induced Calcite Precipitation
Microbial induced calcite precipitation (MICP), a bio-cementation process, can be adopted to improve the engineering properties of granular soils. Bio-stimulation, via directly enriching indigenous ureolytic b...
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Article
Combining Multiple Factors to Predict Alzheimer’s Disease
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Article
Open AccessLilac (Syringa oblata) genome provides insights into its evolution and molecular mechanism of petal color change
Color change during flower opening is common; however, little is understood on the biochemical and molecular basis related. Lilac (Syringa oblata), a well-known woody ornamental plant with obvious petal color cha...
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Article
Mitophagy, a Form of Selective Autophagy, Plays an Essential Role in Mitochondrial Dynamics of Parkinson’s Disease
Parkinson’s disease (PD) is a severe neurodegenerative disorder caused by the progressive loss of dopaminergic neurons in the substantia nigra and affects millions of people. Currently, mitochondrial dysfuncti...
