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Open AccessApplication prospects of the 2BS cell-adapted China fixed rabies virus vaccine strain 2aG4-B40
Rabies is a fatal zoonotic disease whose pathogenesis has not been fully elucidated, and vaccination is the only effective method for protecting against rabies virus infection. Most inactivated vaccines are pr...
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Open AccessDevelopment and validation of a scoring system to predict the mortality of hospitalized patients with SARS-CoV-2 Omicron: a nationwide, multicentre study
The Omicron variant broke out in China at the end of 2022, causing a considerable number of severe cases and even deaths. The study aimed to identify risk factors for death in patients hospitalized with SARS-C...
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Article
Open AccessOral pimonidazole unveils clinicopathologic and epigenetic features of hypoxic tumour aggressiveness in localized prostate cancer
Tumor hypoxia is associated with prostate cancer (PCa) treatment resistance and poor prognosis. Pimonidazole (PIMO) is an investigational hypoxia probe used in clinical trials. A better understanding of the cl...
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Open AccessAdvancements in understanding the association of sepsis with heart rate variability in premature infants
With the rapid development of perinatal medicine and neonatal resuscitation technology, neonatal mortality gradually reduces, but sepsis is still a neonatal critical illness and an important cause of death. Th...
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Article
Erratum to: Efficient and stable perovskite solar cells by build-in π-columns and ionic interfaces in covalent organic frameworks
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Open AccessNano-frictional mechano-reinforcing porous nanowires scaffolds
Artificial biomaterials with dynamic mechano-responsive behaviors similar to those of biological tissues have been drawing great attention. In this study, we report a TiO2-based nanowire (TiO2NWs) scaffolds, whic...
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Article
Open AccessRole of liver FGF21-KLB signaling in ketogenic diet-induced amelioration of hepatic steatosis
The effectiveness of ketogenic diet (KD) in ameliorating fatty liver has been established, although its mechanism is under investigation. Fibroblast growth factor 21 (FGF21) positively regulates obesity-associ...
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Open AccessPrognostic value of ferritin in ASCT MM patients: integration with GEP models and ISS series systems
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Open AccessUsing a longitudinal network structure to subgroup depressive symptoms among adolescents
Network modeling has been proposed as an effective approach to examine complex associations among antecedents, mediators and symptoms. This study aimed to investigate whether the severity of depressive symptom...
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Article
Open AccessBispecific BCMA/CD24 CAR-T cells control multiple myeloma growth
Anti-multiple myeloma B cell maturation antigen (BCMA)-specific chimeric antigen receptor (CAR) T-cell therapies represent a promising treatment strategy with high response rates in myeloma. However, durable c...
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Article
Open AccessProof of Aerobically Autoxidized Self-Charge Concept Based on Single Catechol-Enriched Carbon Cathode Material
An air-breathing chemical self-charge concept of oxygen-enriched carbon cathode.
The oxygen-enriched carbon mater...
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Article
Open AccessRenomegaly and acute kidney injury as primary manifestations of non-Hodgkin’s lymphoma: a report of three cases
In adults with non-Hodgkin's lymphoma, renal enlargement and acute kidney injury occur infrequently at first presentation, especially in T lymphocytic lymphomas.
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Open AccessAssociation of elevated levels of peripheral complement components with cortical thinning and impaired logical memory in drug-naïve patients with first-episode schizophrenia
Schizophrenia has been linked to polymorphism in genes encoding components of the complement system, and hyperactive complement activity has been linked to immune dysfunction in schizophrenia patients. Whether...
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Article
Open AccessCost-Effectiveness of Secukinumab Versus Other Biologics in the Treatment of Moderate-to-Severe Plaque Psoriasis: The Chinese Healthcare System Perspective
This study assessed the cost-effectiveness of secukinumab compared with other biologics (adalimumab, infliximab, ustekinumab, ixekizumab, guselkumab, and Yisaipu [etanercept biosimilar]) for moderate-to-severe...
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Article
Open AccessTargeting Aspergillus allergen oryzin with a chemical probe at atomic precision
We report the molecular basis of Aspergillus fumigatus oryzin, allergen Asp f 13, or alkaline proteinase ALP1, containing the sequence motif His–Asp–Ser of the subtilisin family, structure, and function at atomic...
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Article
Open AccessA deformability-based biochip for precise label-free stratification of metastatic subtypes using deep learning
Cellular deformability is a promising biomarker for evaluating the physiological state of cells in medical applications. Microfluidics has emerged as a powerful technique for measuring cellular deformability. ...
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Article
Open AccessRetraction Note: CYPA promotes the progression and metastasis of serous ovarian cancer (SOC) in vitro and in vivo
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13048-019-0593-2.
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Open AccessEpidemiological analysis of death among patients on maintenance hemodialysis: results from the bei**g blood purification quality Control and Improvement Center
China has the largest number of patients on maintenance hemodialysis (MHD) worldwide. Despite continuous improvements in hemodialysis techniques, patients on MHD have a higher mortality rate than the general p...
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Open AccessEffect of dialytic phosphate reduction rate on mortality in maintenance hemodialysis patients: a matched case–control study
Phosphates, similar to urea, are small molecular substances that can be cleared during dialysis. Dialytic phosphate reduction rate (PRR) may, to some extent, be related to the relative amount of phosphates cle...
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Open AccessExtracellular status of thrombospondin-2 in type 2 diabetes mellitus and utility as a biomarker in the determination of early diabetic kidney disease
Thrombospondin-2 (TSP-2) is a multifunctional matricellular glycoprotein correlated with glucose homeostasis, insulin sensitivity, and estimated glomerular filtration rate. Investigation of the association of ...
