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  1. No Access

    Article

    Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

    Chimeric antigen receptor T cells (CAR-T cells) have emerged as a powerful treatment option for individuals with B cell malignancies but have yet to achieve success in treating acute myeloid leukemia (AML) due...

    Adrian Gottschlich, Moritz Thomas, Ruth Grünmeier, Stefanie Lesch… in Nature Biotechnology (2023)

  2. Article

    Open Access

    A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model

    Multiple sclerosis (MS) involves the infiltration of autoreactive T cells into the CNS, yet we lack a comprehensive understanding of the signaling pathways that regulate this process. Here, we conducted a geno...

    Arek Kendirli, Clara de la Rosa, Katrin F. Lämmle, Klara Eglseer… in Nature Neuroscience (2023)

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